Kisspeptin as a promising oocyte maturation trigger for in vitro fertilisation in humans

Kasum, Miro and Franulić, Daniela and Čehić, Ermin and Orešković, Slavko and Lila, Albert and Ejubović, Emina (2017) Kisspeptin as a promising oocyte maturation trigger for in vitro fertilisation in humans. Gynecological Endocrinology, 33 (8). pp. 583-587. ISSN 0951-3590

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The aim of this review is to analyse the effectiveness of exogenous kisspeptin administration as a novel alternative of triggering oocyte maturation, instead of currently used triggers such as human chorionic gonadotropin (hCG) or gonadotropin releasing hormone (GnRH) agonist, in women undergoing in vitro fertilisation (IVF) treatment. Kisspeptin has been considered a master regulator of two modes of GnRH and hence gonadotropin secretion, pulses and surges. Administration of kisspeptin-10 and kisspeptin-54 induces the luteinising hormone (LH) surge required for egg maturation and ovulation in animal investigations and LH release during the preovulatory phase of the menstrual cycle and hypothalamic amenorrhoea in humans. Exogenous kisspeptin-54 has been successfully administered as a promising method of triggering oocyte maturation, following ovarian stimulation with gonadotropins and GnRH antagonists in women undergoing IVF, due to its efficacy considering achieved pregnancy rates compared to hCG and GnRH agonists. Also, its safety in patients at high risk of developing ovarian hyperstimulation syndrome is noteworthy. Nevertheless, further studies would be desirable to establish the optimal trigger of egg maturation and to improve the reproductive outcome for women undergoing IVF treatment.

Item Type: Article
MeSH: Adult ; Animals ; Female ; Fertility Agents, Female/adverse effects ; Fertility Agents, Female/metabolism ; Fertility Agents, Female/therapeutic use ; Fertilization in Vitro/adverse effects ; Humans ; Infertility, Female/therapy ; Kisspeptins/adverse effects ; Kisspeptins/genetics ; Kisspeptins/metabolism ; Kisspeptins/therapeutic use ; Oogenesis/drug effects ; Ovarian Hyperstimulation Syndrome/chemically induced ; Ovarian Hyperstimulation Syndrome/epidemiology ; Ovarian Hyperstimulation Syndrome/prevention & control ; Ovulation/drug effects ; Ovulation Induction/adverse effects ; Peptide Fragments/adverse effects ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Peptide Fragments/therapeutic use ; Pregnancy ; Pregnancy Rate ; Recombinant Proteins/adverse effects ; Recombinant Proteins/metabolism ; Recombinant Proteins/therapeutic use ; Risk
Departments: Katedra za ginekologiju i opstetriciju
Depositing User: Martina Žužak
Status: Published
Franulić, DanielaUNSPECIFIED
Orešković, SlavkoUNSPECIFIED
Ejubović, EminaUNSPECIFIED
Date: August 2017
Date Deposited: 23 Sep 2019 07:06
Last Modified: 19 Aug 2020 08:35
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