First case of imported chikungunya infection in Croatia, 2016

Lukšić, Boris and Pandak, Nenad and Dražić-Maras, Edita and Karabuva, Svjetlana and Radić, Mislav and Babić-Erceg, Andrea and Barbić, Ljubo and Stevanović, Vladimir and Vilibić-Čavlek, Tatjana (2017) First case of imported chikungunya infection in Croatia, 2016. International Medical Case Reports Journal, 10. pp. 117-121. ISSN 1179-142X

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In recent years, several European countries reported cases of imported chikungunya infection. We present the first imported clinically manifested chikungunya fever in Croatia. A 27-year-old woman returned to Croatia on 21 March 2016, after she stayed in Costa Rica for two months where she had noticed a mosquito bite on her left forearm. Five days after the mosquito bite she developed severe arthralgias, fever and erythematous papular rash. In next few days symptoms gradually subsided. After ten days she felt better, but arthralgias re-appeared accompanied with morning stiffness. Two weeks after the onset of the disease she visited the infectious diseases outpatient department. The physical examination revealed rash on the trunk, extremities, palms and soles. Laboratory findings showed slightly elevated liver transaminases. Serological tests performed on day 20 after disease onset showed a high titer of chikungunya virus (CHIKV) IgM and IgG antibodies which indicated CHIKV infection. CHIKV-RNA was not detected. Serology to dengue and Zika virus was negative. The patient was treated with nonsteroid anti-inflammatory drugs and paracetamol. Her symptoms ameliorated, however, three months later she still complaint of arthralgias. The presented case highlights the need for inclusion of CHIKV in the differential diagnosis of arthralgia in all travelers returning from countries with documented CHIKV transmission.

Item Type: Article
Additional Information: © 2017 Lukšić et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (
Departments: Katedra za medicinsku mikrobiologiju i parazitologiju
Depositing User: Martina Žužak
Status: Published
Dražić-Maras, EditaUNSPECIFIED
Karabuva, SvjetlanaUNSPECIFIED
Babić-Erceg, AndreaUNSPECIFIED
Stevanović, VladimirUNSPECIFIED
Vilibić-Čavlek, TatjanaUNSPECIFIED
Date: 3 April 2017
Date Deposited: 21 Mar 2018 10:28
Last Modified: 20 Aug 2020 07:33
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