Expression of BMP-2 in vascular endothelial cells of recipient may predict delayed graft function after renal transplantation

Bašić-Jukić, Nikolina and Gulin, Marijana and Hudolin, Tvrtko and Kaštelan, Željko and Katalinić, Lea and Ćorić, Marijana and Varnai, Veda Marija and Ivković, Vanja and Kes, Petar and Jelaković, Bojan (2016) Expression of BMP-2 in vascular endothelial cells of recipient may predict delayed graft function after renal transplantation. Kidney & Blood Pressure Research, 41 (6). pp. 781-793. ISSN 1420-4096

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BACKGROUND/AIMS: Delayed graft function (DGF) is associated with adverse outcomes after renal transplantation. Bone morphogenetic protein-2 (BMP-2) is involved in both endothelial function and immunological events. We compared expression of BMP-2 in epigastric artery of renal transplant recipients with immediate graft function (IGF) and DGF. ----- METHODS: 79 patients were included in this prospective study. Patients were divided in IGF group (64 patients) and DGF group (15 patients). BMP-2 expression in intima media (BMP2m) and endothelium (BMP2e) of epigastric artery was assessed by immunohistochemistry. ----- RESULTS: Lower intensity of BMP2e staining was recorded in DGF compared to IGF. In DGF patients, 93% had no expression of BMP2e and 7% had 1st grade expression, compared to 45% and 41% in IGF group, respectively (P=0.001) (P<0.001 for no expression and P = 0.015 for 1st grade expression). Patients who had BMP2e staining positive had lower odds for DGF (OR 0.059 [0.007, 0.477]) and this remained significant even after adjustment for donor and recipient variables, cold ischemia time, and immunological matching (OR 0.038 [0.003, 0.492]). ----- CONCLUSIONS: Our results demonstrate that BMP-2 expression in endothelial cells of epigastric arteries may predict development of DGF.

Item Type: Article
Additional Information: This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) ( Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.
MeSH: Adult ; Aged ; Bone Morphogenetic Protein 2/analysis ; Delayed Graft Function/diagnosis ; Endothelial Cells/chemistry ; Endothelial Cells/metabolism ; Epigastric Arteries/metabolism ; Female ; Humans ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies
Departments: Katedra za internu medicinu
Katedra za urologiju
Depositing User: Martina Žužak
Status: Published
Bašić-Jukić, NikolinaUNSPECIFIED
Gulin, MarijanaUNSPECIFIED
Hudolin, TvrtkoUNSPECIFIED
Kaštelan, ŽeljkoUNSPECIFIED
Ćorić, MarijanaUNSPECIFIED
Varnai, Veda MarijaUNSPECIFIED
Jelaković, BojanUNSPECIFIED
Date: 2016
Date Deposited: 21 Mar 2018 10:21
Last Modified: 10 Aug 2020 07:47
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