Potočnjak, Ines and Trbušić, Matias and Dokoza Terešak, Sanda and Radulović, Bojana and Pregartner, Gudrun and Berghold, Andrea and Tiran, Beate and Marsche, Gunther and Degoricija, Vesna and Frank, Saša (2017) Metabolic syndrome modulates association between endothelial lipase and lipid/lipoprotein plasma levels in acute heart failure patients. Scientific Reports, 7 (1). p. 1165. ISSN 2045-2322
![[img]](http://medlib.mef.hr/style/images/fileicons/application_pdf.png) |
PDF
- Published Version
Download (1MB) |
Abstract
We hypothesised that the established association of endothelial lipase (EL) plasma levels with atherogenic lipid profile is altered in acute heart failure (AHF) and additionally affected by overlapping metabolic syndrome (MetS). We examined the association of EL plasma levels and lipid/lipoprotein plasma levels in AHF patients without and with overlapping MetS. The study was performed as a single-centre, observational study on 152 AHF patients, out of which 85 had overlapping MetS. In the no-MetS group, EL plasma levels were significantly positively correlated with plasma levels of atherogenic lipids/lipoproteins, including total cholesterol, low-density lipoprotein (LDL)-cholesterol, total LDL particles and triglycerides, but also with plasma levels of antiatherogenic high-density lipoprotein (HDL)-cholesterol, total HDL particles and small HDL particles. In the MetS group, EL plasma levels were positively correlated with triglyceride and small LDL-particle levels, and significantly negatively correlated with plasma levels of large HDL particles as well as with LDL- and HDL-particle size, respectively. EL- and lipid/lipoprotein- plasma levels were different in the no-MetS patients, compared to MetS patients. The association of EL with atherogenic lipid profile is altered in AHF and additionally modified by MetS, which strongly modulates EL- and lipid/lipoprotein-plasma levels in AHF.
| Item Type: | Article | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Additional Information: | Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2017 | ||||||||||||||||||||||
| Departments: | Katedra za internu medicinu | ||||||||||||||||||||||
| Depositing User: | Martina Žužak | ||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||
| Creators: |
|
||||||||||||||||||||||
| Date: | 26 April 2017 | ||||||||||||||||||||||
| Date Deposited: | 14 Mar 2018 10:44 | ||||||||||||||||||||||
| Last Modified: | 20 Aug 2020 09:08 | ||||||||||||||||||||||
| Subjects: | UNSPECIFIED | ||||||||||||||||||||||
| Related URLs: | |||||||||||||||||||||||
| URI: | http://medlib.mef.hr/id/eprint/2847 |
Actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
