Intracranial thrombus morphology and composition undergoes time-dependent changes in acute ischemic stroke: a CT densitometry study

Pikija, Slaven and Magdič, Jožef and Trkulja, Vladimir and Unterkreuter, Peter and Mutzenbach, Johannes and Novak, Helmut and Weymayr, Friedrich and Hauer, Larissa and Sellner, Johann (2016) Intracranial thrombus morphology and composition undergoes time-dependent changes in acute ischemic stroke: a CT densitometry study. International Journal of Molecular Sciences, 17 (11). E1959. ISSN 1422-0067

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Abstract

The aim of our study was to assess whether cerebral artery clots undergo time-dependent morphological and compositional changes in acute ischemic stroke. We performed a retrospective chart review of patients admitted within 5 h from symptom onset to three European stroke centers and evaluated non-contrast-enhanced CT (NECT) for hyperdense artery signs (HAS) in 2565 scans. The occlusion site, density of HAS expressed in Hounsfield units (HU), area of HAS, and relative density (rHU) (HU clot/HU non-affected artery) were studied and related to time from symptom onset, clinical severity, stroke etiology, and laboratory parameters. A HAS was present in the middle cerebral artery (MCA) in 185 (7.2%) and further explored. The mean time from symptom onset to CT was 100 min (range 17-300). We found a time-dependent loss of density in the occluded M1 segment within the first 5 h (N = 118, 95% CI [-15, -2], p = 0.01). Further, the thrombus area in the M2 segment decreased with time (cubic trend N = 67, 95% CI [-63, -8], p = 0.02). Overall, and especially in the M2 segment, a lower clot area was associated with higher fibrinogen (-21.7%, 95% CI [-34.8, -5.8], p = 0.009). In conclusion, our results disclosed time-dependent changes of intracranial thrombi with regard to occlusion site, density and area.

Item Type: Article
Additional Information: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license(http://creativecommons.org/licenses/by/4.0/).
MeSH: Adult ; Aged ; Aged, 80 and over ; Biomarkers/metabolism ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/pathology ; Female ; Fibrinogen/metabolism ; Humans ; Intracranial Thrombosis/diagnostic imaging ; Intracranial Thrombosis/pathology ; Male ; Middle Aged ; Middle Cerebral Artery/diagnostic imaging ; Middle Cerebral Artery/pathology ; Neuroimaging ; Retrospective Studies ; Severity of Illness Index ; Stroke/diagnostic imaging ; Stroke/pathology ; Tomography, X-Ray Computed
Departments: Katedra za farmakologiju
Depositing User: Martina Žužak
Status: Published
Creators:
CreatorsEmail
Pikija, SlavenUNSPECIFIED
Magdič, JožefUNSPECIFIED
Trkulja, VladimirUNSPECIFIED
Unterkreuter, PeterUNSPECIFIED
Mutzenbach, JohannesUNSPECIFIED
Novak, HelmutUNSPECIFIED
Weymayr, FriedrichUNSPECIFIED
Hauer, LarissaUNSPECIFIED
Sellner, JohannUNSPECIFIED
Date: 23 November 2016
Date Deposited: 14 Mar 2018 10:41
Last Modified: 13 Aug 2020 07:00
Subjects: UNSPECIFIED
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2844

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