IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis

Pačić, Arijana and Šenjug, Petar and Bacalja, Jasna and Tišljar, Miroslav and Horvatić, Ivica and Bulimbašić, Stela and Knotek, Mladen and Galešić, Krešimir and Galešić Ljubanović, Danica (2017) IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis. Croatian Medical Journal, 58 (4). pp. 281-291. ISSN 0353-9504

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Abstract

AIM: To determine the role of immunoglobulin M (IgM) deposits in clinical manifestations, disease outcome, and treatment response of idiopathic and secondary focal segmental glomerulosclerosis (FSGS). ----- METHODS: Kidney biopsy specimens of 171 patients diagnosed with FSGS (primary and secondary) and 50 control patients were retrospectively included in the study. For each patient, clinical and outcome data were obtained and compared to morphological parameters, including immunofluorescence analysis of mesangial IgM and complement 3 (C3) deposits analyzed on kidney biopsy samples. ----- RESULTS: There were significant positive correlations between IgM and C3 deposition in secondary FSGS (P<0.001) and between IgM and mesangial deposits detected by electron microscopy in secondary FSGS (P=0.015), which indicated that higher IgM deposition correlated with higher C3 deposition and mesangial deposits only in secondary FSGS. Patients with secondary FSGS and the deposition of IgM showed inferior renal outcomes at earlier time points in comparison with patients with negative IgM expression (P=0.022). ----- CONCLUSIONS: We detected a positive correlation between IgM and C3 in secondary FSGS. The association between IgM deposition and worse renal outcome in secondary FSGS indicates that IgM may play a role in the progression of this disease.

Item Type: Article
MeSH: Adolescent ; Adult ; Biomarkers/metabolism ; Case-Control Studies ; Complement C3/metabolism ; Disease Progression ; Female ; Glomerulosclerosis, Focal Segmental/immunology ; Glomerulosclerosis, Focal Segmental/pathology ; Humans ; Immunoglobulin M/metabolism ; Kidney/metabolism ; Kidney/pathology ; Male ; Mesangial Cells/metabolism ; Mesangial Cells/pathology ; Middle Aged ; Retrospective Studies
Departments: Katedra za internu medicinu
Katedra za patologiju
Depositing User: Martina Žužak
Status: Published
Creators:
CreatorsEmail
Pačić, ArijanaUNSPECIFIED
Šenjug, PetarUNSPECIFIED
Bacalja, JasnaUNSPECIFIED
Tišljar, MiroslavUNSPECIFIED
Horvatić, IvicaUNSPECIFIED
Bulimbašić, StelaUNSPECIFIED
Knotek, MladenUNSPECIFIED
Galešić, KrešimirUNSPECIFIED
Galešić Ljubanović, DanicaUNSPECIFIED
Date: 31 August 2017
Date Deposited: 14 Mar 2018 10:30
Last Modified: 20 Aug 2020 08:05
Subjects: UNSPECIFIED
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2840

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