Clinicopathologic correlation of oral lichen planus and oral lichenoid lesions: a preliminary study

Mravak-Stipetić, Marinka and Lončar-Brzak, Božana and Bakale-Hodak, Iva and Sabol, Ivan and Seiwerth, Sven and Majstorović, Martina and Grce, Magdalena (2014) Clinicopathologic correlation of oral lichen planus and oral lichenoid lesions: a preliminary study. The Scientific World Journal, 2014. p. 746874. ISSN 2356-6140

[img] PDF - Published Version
Download (1MB)


Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are clinically and histologically similar lesions but their treatment planning and prognosis are different. The review of the literature indicates numerous criteria to distinguish these two lesions; however there is a lot of inconsistency. Thus, the aim of this study was to determine the correlation of histopathology and clinical OLP and OLL diagnosis and to clarify which histopathologic criteria could best distinguish these two diagnoses. A retrospective study showed that clinically diagnosed 92 OLPs and 14 OLLs have been confirmed histopathologically in 52.2% and 42.9% of cases, respectively. In addition, histopathology showed statistically significant more eosinophils (P<0.0005), plasma cells (P<0.0005), and granulocytes (P<0.05) in OLL than OLP. To establish histopathological diagnosis of OLP and OLL it should be mandatory to define the type of cells in mononuclear infiltrate, which can be associated more accurately with clinical feature and patient history. Therefore, currently accepted diagnostic criteria for OLP and OLL should be modified and validated on a larger number of patients taking into account particular distinguishing histopathological features.

Item Type: Article
Additional Information: © 2014 Marinka Mravak-Stipetić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
MeSH: Female ; Humans Lichen Planus, Oral/diagnosis ; Lichen Planus, Oral/pathology ; Male ; Middle Aged ; Mouth/pathology
Departments: Katedra za patologiju
Depositing User: Martina Žužak
Status: Published
Mravak-Stipetić, MarinkaUNSPECIFIED
Lončar-Brzak, BožanaUNSPECIFIED
Bakale-Hodak, IvaUNSPECIFIED
Majstorović, MartinaUNSPECIFIED
Grce, MagdalenaUNSPECIFIED
Date: 2014
Date Deposited: 14 Mar 2018 10:29
Last Modified: 17 Jul 2020 09:56
Related URLs:

Actions (login required)

View Item View Item


Downloads per month over past year