A rapid biochemical and radiological response to the concomitant therapy with temozolomide and radiotherapy in an aggressive ACTH pituitary adenoma

Mišir Krpan, Ana and Dušek, Tina and Rakušić, Zoran and Solak, Mirsala and Kraljevic, Ivana and Bišof, Vesna and Ozretić, David and Kaštelan, Darko (2017) A rapid biochemical and radiological response to the concomitant therapy with temozolomide and radiotherapy in an aggressive ACTH pituitary adenoma. Case Reports in Endocrinology, 2017. p. 2419590. ISSN 2090-6501

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Abstract

Background and Importance: In the last eight years temozolomide (TMZ) has been used as the last-line treatment modality for aggressive pituitary tumors to be applied after the failure of surgery, medical therapy, and radiotherapy. The objective was to achieve a rapid control of tumor growth and hormone normalization with concurrent chemoradiotherapy in a patient with very aggressive ACTH pituitary adenoma. ----- Clinical Presentation: We describe a patient with an aggressive ACTH-producing adenoma treated with concurrent temozolomide and radiotherapy. The patient suffered from an aggressive ACTH adenoma resistant to surgical and medical treatment. After two months of concurrent temozolomide and radiotherapy, cortisol normalization and significant tumor shrinkage were observed. After 22 months of follow-up, there is still no evidence of tumor recurrence. ----- Conclusion: Concurrent treatment with temozolomide and irradiation appears to be highly effective in the achievement of the tumor volume control as well as in the control of ACTH secretion in aggressive ACTH adenoma.

Item Type: Article
Additional Information: © 2017 Ana Mišir Krpan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Departments: Katedra za internu medicinu
Katedra za radiologiju i opću kliničku onkologiju
Depositing User: Martina Žužak
Status: Published
Creators:
CreatorsEmail
Mišir Krpan, AnaUNSPECIFIED
Dušek, TinaUNSPECIFIED
Rakušić, ZoranUNSPECIFIED
Solak, MirsalaUNSPECIFIED
Kraljevic, IvanaUNSPECIFIED
Bišof, VesnaUNSPECIFIED
Ozretić, DavidUNSPECIFIED
Kaštelan, DarkoUNSPECIFIED
Date: 2017
Date Deposited: 02 Mar 2018 09:42
Last Modified: 20 Aug 2020 07:48
Subjects: UNSPECIFIED
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2826

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