Helicobacter pylori infection and severity of coronary atherosclerosis in patients with chronic coronary artery disease

Jukić, Anita and Božić, Dorotea and Kardum, Duško and Bečić, Tina and Lukšić, Bruno and Vrsalović, Mislav and Ljubković, Marko and Fabijanić, Damir (2017) Helicobacter pylori infection and severity of coronary atherosclerosis in patients with chronic coronary artery disease. Therapeutics and Clinical Risk Management, 13. pp. 933-938. ISSN 1178-203X

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AIM: Controversy exists concerning the relation between Helicobacter pylori (HP) infection and coronary artery disease (CAD). We aimed to examine the relationship between HP infection and severity of coronary atherosclerosis in patients with chronic CAD. ----- PATIENTS AND METHODS: A total of 150 patients (109 [73%] men; mean age 62.61±10.23 years) scheduled for coronary artery bypass grafting surgery were consecutively enrolled in the cross-sectional study. According to rapid urease test and/or gastric biopsy samples stained with hematoxylin and eosin and according to Giemsa, patients were classified as HP positive (n=87; 58%) or HP negative (n=63; 42%). Coronary angiograms were scored by quantitative assessment, using multiple angiographic scoring system: 1) vessel score (number of coronary arteries stenosed ≥50%), 2) Gensini score (assigning a severity score to each coronary stenosis according to the degree of luminal narrowing and its topographic importance) and 3) angiographic severity score (number of coronary artery segments stenosed ≥50%). ----- RESULTS: In comparison to HP-negative patients, HP-positive patients were more frequently hypertensive (P=0.014), had higher values of systolic (P=0.043) and diastolic (P=0.005) blood pressure and total cholesterol (P=0.013) and had lower values of high-density lipoprotein-cholesterol (HDL-C; P=0.010). There were no significant differences between the groups in the severity of coronary atherosclerosis: vessel score (P=0.152), Gensini score (P=0.870) and angiographic severity score (P=0.734). ----- CONCLUSION: It is likely that HP infection is not a risk factor for the severity of coronary atherosclerosis in chronic CAD patients.

Item Type: Article
Additional Information: © 2017 Jukić et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
Departments: Katedra za internu medicinu
Depositing User: Martina Žužak
Status: Published
Vrsalović, MislavUNSPECIFIED
Ljubković, MarkoUNSPECIFIED
Fabijanić, DamirUNSPECIFIED
Date: 27 July 2017
Date Deposited: 02 Mar 2018 09:23
Last Modified: 19 Aug 2020 08:20
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2822

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