Association of chronic kidney disease with periprocedural myocardial injury after elective stent implantation: a single center prospective cohort study

Jerkić, Helena and Letilović, Tomislav and Stipinović, Mario and Počanić, Darko and Ćatić, Jasmina and Knotek, Mladen (2016) Association of chronic kidney disease with periprocedural myocardial injury after elective stent implantation: a single center prospective cohort study. Medicine, 95 (45). e5381. ISSN 0025-7974

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Coronary artery disease (CAD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Patients with CKD who undergo percutaneous coronary intervention (PCI) may have more ischemic events than patients without CKD. The aim of our study was to determine the incidence of periprocedural myocardial injury (PMI) after elective stent implantation in patients with CKD using the Third Joint ESC/ACCF/AHA/WHF PMI definition.In a single center prospective cohort study, we enrolled 344 consecutive patients who underwent elective PCI in a period of 39 months. Serum troponin I (cTnI) concentrations were measured at baseline and at 8 and 16 hours after PCI. Periprocedural increase of cTnI, according to the most recent PMI definition, was used to define both the presence and intensity of PMI. Patients were further stratified according to the estimated glomerular filtration rate (eGFR) using 4 variable Modification of Diet in Renal Disease (MDRD) equation: control group with eGFR >90 mL/min/1.73 m and the CKD group with eGFR < 90 mL/min/1.73 m, with further subdivision according to the CKD stage.We found no significant difference in the incidence as well as intensity of the PMI in the control (>90 mL/min/1.73 m) and the CKD group (<90 mL/min/1.73 m) both 8 and 16 hours after PCI. When the CKD patients were further subdivided according to their CKD stage, there was again no difference in the intensity or incidence of PMI compared to the control group. Further analyses of our data showed angina pectoris CCS IV, bare metal stent (BMS) implantation, and treatment with angiotensin-converting enzyme inhibitors (ACEI) as independent predictors of PMI. Furthermore, the presence of hypertension was inversely related to the occurrence of PMI.Applying the new guidelines for PMI and using the eGFR equation most suitable for our patients, we found no association between PMI and CKD. Further analyses showed other factors that could potentially influence the occurrence of PMI.

Item Type: Article
Additional Information: Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
MeSH: Aged ; Cohort Studies ; Elective Surgical Procedures ; Female ; Heart Injuries/epidemiology ; Heart Injuries/etiology ; Humans ; Incidence ; Male ; Middle Aged ; Percutaneous Coronary Intervention/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Prospective Studies ; Prosthesis Implantation/adverse effects ; Renal Insufficiency, Chronic/complications ; Stents
Departments: Katedra za internu medicinu
Depositing User: Martina Žužak
Status: Published
Letilović, TomislavUNSPECIFIED
Stipinović, MarioUNSPECIFIED
Date: November 2016
Date Deposited: 02 Mar 2018 09:21
Last Modified: 11 Aug 2020 08:09
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