The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus

Božek, Tomislav and Blažeković, Antonela and Nikolac Perković, Matea and Gotovac Jerčić, Kristina and Šustar, Aleksandra and Smirčić-Duvnjak, Lea and Outeiro, Tiago F. and Pivac, Nela and Borovečki, Fran (2017) The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus. Diabetology & Metabolic Syndrome, 9. p. 97. ISSN 1758-5996

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Official URL: https://doi.org/10.1186/s13098-017-0295-0

Abstract

Background: Type II diabetes is an important health problem with a complex connection to obesity, leading to a broad range of cardiovascular complications. Insulin therapy often results in weight gain and does not always ensure adequate glycemic control. However, previous studies reported that insulin detemir is an efficient long-acting insulin with a weight sparing effect. The aim of this study was to determine the association of catechol O-methyltransferase (COMT) Val108/158Met and dopamine-beta-hydroxylase (DBH) 1021C/T polymorphisms with the effectiveness of insulin detemir in achieving glucose control and body weight control. Participants and methods: This 52-week observational study included 185 patients with inadequate glycemic control treated with premix insulin analogues, which were replaced with insulin aspart and insulin detemir, and 156 healthy controls. After DNA isolation from blood samples, genotyping of DBH-1021C/T polymorphism (rs1611115) and COMT Val108/158Met polymorphism (rs4680) was performed. ----- Results: Our results confirmed that insulin detemir did not lead to weight gain. The most significant finding was that A carriers (the combined AG and AA genotype) of the COMT Val108/158Met achieved significantly better hemoglobin A1c (HbA1c) values compared to patients carrying GG genotype. No association between DBH-1021C/T genotypes and weight and/or glucose control was detected in diabetes patients or in healthy control subjects. ----- Conclusions: This study showed that the presence of one or two A allele of the COMT Val108/158Met was associated with improved glycemic response, and with a better response to insulin detemir therapy in patients with type II diabetes, separating them as best candidates for detemir therapy.

Item Type:

Article

Additional Information:

© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Departments:

Centar za translacijska i klinička istraživanja
Katedra za internu medicinu

Depositing User:

Martina Žužak

Status:

Published

Creators:

Creators	Email
Božek, Tomislav	UNSPECIFIED
Blažeković, Antonela	UNSPECIFIED
Nikolac Perković, Matea	UNSPECIFIED
Gotovac Jerčić, Kristina	UNSPECIFIED
Šustar, Aleksandra	UNSPECIFIED
Smirčić-Duvnjak, Lea	UNSPECIFIED
Outeiro, Tiago F.	UNSPECIFIED
Pivac, Nela	UNSPECIFIED
Borovečki, Fran	UNSPECIFIED

Date:

4 December 2017

Date Deposited:

26 Jan 2018 10:14

Last Modified:

17 Aug 2020 08:44

Subjects:

UNSPECIFIED

Related URLs:

Publisher

URI:

http://medlib.mef.hr/id/eprint/2804

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