Metabolic parameters and fetal development in offspring of mothers with gestational diabetes

Mulliqi Kotori, Vjosa (2016) Metabolic parameters and fetal development in offspring of mothers with gestational diabetes. PhD thesis, Sveučilište u Zagrebu.

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Abstract

Introduction: Increasing incidence of GDM and LGA births predispose children for obesity related diseases, metabolic syndrome and type 2 Diabetes. Aims: The aim of the study was to investigate the cause of enhanced fetal growth (>90 centiles)in well controlled gestational diabetic pregnancies. Subjects and methods: 37 GDM mothers and 46 healthy control subjects and their newborns participated in the cross sectional study. Blood samples were taken from mother before delivery and from neonates at the time of delivery and tested for concentration of adiponectin, leptin, insulin, c peptide, cholesterol, triglycerides, HDL and LDL cholesterol. Results: Gestational diabetic mothers had significantly higher BMI (first trimester) than a control group (29.6 ±6.0 vs. 23.3 ± 4.3, P<0.0001) and adiponectin concentration were significantly lower in gestational diabetic mothers compared with healthy control subjects (10871.3 ± 5184.2 vs. 13418.9 ± 5148.6, P=0.021). In offspring of GDM concentration of adiponectin (24469.0 ± 10478.8 vs. 45359.6 ± 7592, P=0.0017) is significantly lower in LGA newborns of GDM mothers compared with LGA newborns of healthy control; and concentration of Insulin is significantly higher in AGA (11.3 ±14.1 vs.4.3 ±3.2, P<0.0001) and LGA (12.9 ±6.4 vs. 5.8 ±2.9, P=0.035) newborn of GDM mothers compared with AGA and LGA newborns of healthy control. Conclusions: The findings of this study describe an altered metabolic environment for the fetus even in well controlled GDM mothers. Hyperinsulinemia and hypoadiponectinemia in macrosomic infants are predisposing factors that can contribute in development of obesity related disorder later in their life.

Abstract in Croatian

Uvod:Povecanje ucestalosti Diabetesa u trudnoci I makrosomne djece nosi veliki rizik za razvitak bolesti povezane za pretilost kao metabolicki sindrom I tip 2 dijabetesa . Ciljevi: Cilj istraživanja je ispitati uzrok pojacanog fetalnog razvitka( > 90 centile ) kod trudnica sa dobrom kontrollom gestacijskog diabetesa. Pacijenti i Metode: 37 trudne zene sa GDM i 46 zdravih trudnica kao kontrolna grupa I njihova novorodencad su sudjelovali u istrazivanju. Uzorci krvi uzeti su od majke prije poroda i od novorodenih u vrijeme poroda I testirana je koncentracije adiponektina, leptina , insulin , c peptida, kolesterola, triglicerida, HDL i LDL kolesterol. Nalazi: Majke sa diabetesom u trudnoci imaju znacajno veci BMI ( prvotromjesecje ) od kontrolne skupine ( 29,6 ± 6,0 vs. 23,3 ± 4,3 , P < 0,0001 ) , a koncentracija adiponektina su znacajno niže u Majke sa diabetesom u trudnoci u usporedbi sa zdravim kontrolnim ispitanicima ( 10.871,3 ± 5184,2 vs 13.418,9 ± 5148,6 , P = 0,021 ) . U djece majki sa diabetesom koncentracije adiponektina ( 24.469,0 10.478,8 ± vs 45.359,6 ± 7.592 , P = 0.0017 ) su znatno niže kod LGA djece majki s dijabetesom u usporedbi sa LGA djece zdrave kontrolne grupe ; I koncentracija inzulina je znacajno viša u AGA ( 11,3 ± 14,1 vs.4.3 ± 3,2 , P < 0,0001 ) i LGA ( 12,9 ± 6,4 vs 5,8 ± 2,9 , P = 0,035 ) djece majki s diabetesom u usporedbi sa AGA i LGA djece zdrave kontrolne grupe. Zakljucak::Nalazi ovog istraživanja opisuju metabolicke promene koje okružuju plod I kod dobro kontroliranog diabetesa u trudnoci . Hiperinzulinemija I hypoadiponectinemia u makrosomne dojencadi su predisponirajuci cimbenici koji mogu pridonijeti u razvoju bolesti povezane za pretilosti kasnije u životu.

Item Type: Thesis (PhD)
Mentors:
Mentor
Đelmiš, Josip
Departments: Izvan medicinskog fakulteta
Depositing User: dr.med. Helena Markulin
University: Sveučilište u Zagrebu
Institution: Medicinski fakultet
Number of Pages: 45
Status: Unpublished
Creators:
CreatorsEmail
Mulliqi Kotori, VjosaUNSPECIFIED
Date: 24 October 2016
Date Deposited: 18 Jan 2018 08:19
Last Modified: 18 Jan 2018 08:19
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/2783

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