Seroepidemiology of cytomegalovirus infections in Croatia

Vilibić-Čavlek, Tatjana and Kolarić, Branko and Beader, Nataša and Vrtar, Izabela and Tabain, Irena and Mlinarić-Galinović, Gordana (2017) Seroepidemiology of cytomegalovirus infections in Croatia. Wiener Klinische Wochenschrift, 129 (3-4). pp. 129-135. ISSN 0043-5325

[img] PDF - Accepted Version
Download (461kB)


BACKGROUND: Cytomegalovirus (CMV) is endemic worldwide, with marked differences in the seroprevalence rates between countries. The aim of this study was to analyze the seroprevalence of CMV infections in Croatia. ----- METHODS: During a 3-year period (2013-2015) 2438 consecutive serum samples collected from Croatian residents were tested for the presence of CMV IgM and IgG antibodies using enzyme-linked immunoassay. The IgM/IgG positive samples were further tested for IgG avidity. ----- RESULTS: The overall seroprevalence rates for CMV IgG and IgM antibodies were 74.4 % and 4.3 %, respectively. The IgG seroprevalence showed significant differences between population groups: children/adolescents 54.6 %, general adult population 77.2 %, hemodialysis patients 91.4 % (p < 0.001). Seropositivity of CMV was strongly age-dependent with prevalences ranging from 53.0 % in children less than 10 years old to 93.8 % in persons above 60 years (p < 0.001). There was no difference in the prevalence rate between women with normal pregnancy and women with poor obstetric history. Gender and place of residence were not associated with CMV seropositivity. Using IgG avidity, current/recent primary CMV infection was confirmed by a low/borderline avidity index (AI) in 46.7 % participants, while in 53.3 % a high AI indicated CMV reactivation or reinfection. Primary infections were detected mainly in children and adolescents (83.2 % and 70.5 %, respectively), while reactivation/reinfection was common in persons older than 40 (77.0-100 %). Reactivation/reinfection was most commonly detected in hemodialysis patients (92.3 %). Logistic regression showed that older age and being on hemodialysis were significant predictors of CMV seropositivity. ----- CONCLUSION: Infections with CMV are widespread in the Croatian population. Older age and being on hemodialysis appear to be the main risk factors for CMV infection.

Item Type: Article
MeSH: Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Child ; Child, Preschool ; Croatia/epidemiology ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/blood ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/immunology ; Female ; Humans Immunoglobulin G/blood ; Immunoglobulin M/blood ; Infant ; Longitudinal Studies ; Male ; Middle Aged ; Pregnancy ; Pregnancy Complications, Infectious/blood ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/epidemiology ; Prevalence ; Risk Factors ; Seroepidemiologic Studies ; Sex Distribution ; Young Adult
Departments: Katedra za medicinsku mikrobiologiju i parazitologiju
Depositing User: Martina Žužak
Status: Published
Vilibić-Čavlek, TatjanaUNSPECIFIED
Kolarić, BrankoUNSPECIFIED
Mlinarić-Galinović, GordanaUNSPECIFIED
Date: February 2017
Date Deposited: 26 Jan 2018 09:56
Last Modified: 20 Aug 2020 09:45
Related URLs:

Actions (login required)

View Item View Item


Downloads per month over past year