Obesity and hypercholesterolemia in patients with prolactinomas: could DHEA-S and growth hormone be the missing link?

Perić, Božidar and Kruljac, Ivan and Šundalić, Sara and Pećina, Hrvoje Ivan and Jović, Andrijana and Štefanović, Mario and Butorac, Dražan and Vrkljan, Milan (2016) Obesity and hypercholesterolemia in patients with prolactinomas: could DHEA-S and growth hormone be the missing link? Endocrine Research, 41 (3). pp. 200-206. ISSN 0743-5800

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PURPOSE: Increasing evidence exists that hyperprolactinemia alters metabolic profile. The mechanism of this effect is unknown. We aimed to investigate the differences between the metabolic profile of patients with prolactinomas and nonfunctional pituitary adenomas and to evaluate the impact of other pituitary hormones on their metabolic profile. ----- METHODS: Our retrospective study included 86 consecutive patients with prolactinomas and nonfunctional adenomas (29 prolactinomas and 57 adenomas). Body mass index (BMI), blood pressure, serum prolactin, growth hormone (GH), insulin-like growth factor I (IGF-I), adrenocorticotropic hormone (ACTH), cortisol, urinary free cortisol, triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), dehydroepiandrosterone-sulfate (DHEA-S), testosterone in men, triglycerides, total cholesterol, HDL (high-density lipoprotein) cholesterol, LDL (Low-density lipoprotein) cholesterol, alanine-transaminase, aspartate-transaminase, fasting glucose, and C-reactive protein (CRP) were obtained for all patients. Regression analyses were performed on log-transformed data. ----- RESULTS: After adjustment for age, gender, and tumor size, prolactinomas were associated with higher BMI (OR 5.61, 95%CI 1.70-9.51, p = 0.005), LDL cholesterol (OR 3.60, 95%CI 1.35-5.93, p = 0.015), DHEA-S (OR 1.97, 95%CI 1.23-3.72, p = 0.026), and lower GH levels (OR 0.43, 95%CI 0.03-0.84, p = 0.037). In a linear multivariate regression, the association between DHEA-S, GH, and prolactin remained significant even after adjustment for BMI. GH and IGF-I were associated with BMI and LDL cholesterol, but the association diminished after adjustment for serum prolactin. ----- CONCLUSIONS: Prevalence of obesity is four times higher in patients with prolactinomas than in patients with nonfunctional adenomas. Higher DHEA-S and lower GH levels in patients with prolactinomas may have an important role in prolactin-induced metabolic effects. Further studies are needed.

Item Type: Article
MeSH: Adult ; Comorbidity ; Dehydroepiandrosterone Sulfate/blood ; Female ; Human Growth Hormone/blood ; Humans ; Hypercholesterolemia/blood ; Hypercholesterolemia/epidemiology ; Male ; Middle Aged ; Obesity/blood ; Obesity/epidemiology ; Pituitary Neoplasms/blood ; Pituitary Neoplasms/epidemiology ; Prolactin/blood ; Prolactinoma/blood ; Prolactinoma/epidemiology ; Retrospective Studies
Departments: Katedra za internu medicinu
Depositing User: Martina Žužak
Status: Published
Pećina, Hrvoje IvanUNSPECIFIED
Jović, AndrijanaUNSPECIFIED
Štefanović, MarioUNSPECIFIED
Butorac, DražanUNSPECIFIED
Date: August 2016
Date Deposited: 12 Jan 2018 08:16
Last Modified: 13 Aug 2020 06:58
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2767

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