Botulinum toxin type A in motor nervous system: unexplained observations and new challenges

Matak, Ivica and Lacković, Zdravko and Relja, Maja (2016) Botulinum toxin type A in motor nervous system: unexplained observations and new challenges. Journal of Neural Transmission, 123 (12). pp. 1415-1421. ISSN 0300-9564

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Official URL: http://doi.org/10.1007/s00702-016-1611-9

Abstract

In the motor system, botulinum toxin type A (BoNT/A) actions were classically attributed to its well-known peripheral anticholinergic actions in neuromuscular junctions. However, the enzymatic activity of BoNT/A, assessed by the detection of cleaved synaptosomal-associated protein 25 (SNAP-25), was recently detected in motor and sensory regions of the brainstem and spinal cord after toxin peripheral injection in rodents. In sensory regions, the function of BoNT/A activity is associated with its antinociceptive effects, while in motor regions we only know that BoNT/A activity is present. Is it possible that BoNT/A presence in central motor nuclei is without any function? In this brief review, we analyze this question. Limited data available in the literature warrant further investigations of BoNT/A actions in motor nervous system.

Item Type:

Article

MeSH:

Animals ; Botulinum Toxins, Type A / metabolism ; Botulinum Toxins, Type A / pharmacology ; Gene Expression / drug effects ; Humans ; Motor Neurons / drug effects ; Motor Neurons / physiology ; Nervous System / cytology ; Nervous System / drug effects ; Nervous System / metabolism ; Neural Pathways / drug effects ; Neural Pathways / physiology

Departments:

Katedra za farmakologiju
Katedra za neurologiju

Depositing User:

Martina Žužak

Status:

Published

Creators: