Microbiological criteria in non-tuberculous mycobacteria pulmonary disease: a tool for diagnosis and epidemiology

Janković, Mateja and Sabol, Ivan and Žmak, Ljiljana and Katalinić Janković, Vera and Jakopović, Marko and Obrovac, Mihaela and Tićac, Brigita and Kardum Bulat, Ljiljana and Popović Grle, Sanja and Mareković, Ivana and Samaržija, Miroslav and van Ingen, Jakko (2016) Microbiological criteria in non-tuberculous mycobacteria pulmonary disease: a tool for diagnosis and epidemiology. International Journal of Tuberculosis and Lung Disease, 20 (7). pp. 934-940. ISSN 1027-3719

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SETTING: The value of microbiological criteria in diagnosing non-tuberculous mycobacteria pulmonary disease (NTM-PD) and monitoring its epidemiology is unknown. ----- OBJECTIVES: To correlate the rate of NTM-PD based on microbiological criteria (American Thoracic Society/Infectious Diseases Society of America [ATS/IDSA] or stricter microbiological criteria) compared with the full ATS/IDSA criteria, to assess the positive predictive value (PPV) of different microbiological criteria in predicting NTM-PD, and to evaluate the clinical relevance of different NTM species. ----- DESIGN: Retrospective study of all patients with pulmonary NTM isolates in Croatia during an 8-year period. NTM species were divided into low, intermediate and high clinical relevance groups for additional analyses. ----- RESULTS: Good correlation between both microbiological and full ATS/IDSA criteria was observed. The PPV of stricter and ATS/IDSA microbiological criteria was respectively 93.3% and 59.8%. The usefulness of microbiological criteria varied between groups. ATS/IDSA microbiological criteria had a PPV of 89.8% in the high relevance group, while in the intermediate relevance group, the PPV of stricter and ATS/IDSA microbiological criteria was respectively 94.3% and 63.4%. ----- CONCLUSIONS: Microbiological criteria are useful in detecting NTM-PD, allowing laboratory-based monitoring. Stricter criteria should be used for species of low clinical relevance, and less stringent criteria for species of high relevance in the local setting.

Item Type: Article
MeSH: Adolescent ; Adult ; Aged ; Bacteriological Techniques ; Child ; Child, Preschool ; Croatia / epidemiology ; Female ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Mycobacterium Infections, Nontuberculous / diagnosis ; Mycobacterium Infections, Nontuberculous / epidemiology ; Mycobacterium Infections, Nontuberculous / microbiology ; Nontuberculous Mycobacteria / classification ; Nontuberculous Mycobacteria / isolation & purification ; Predictive Value of Tests ; Prevalence ; Reproducibility of Results ; Respiratory Tract Infections / diagnosis ; Respiratory Tract Infections / epidemiology ; Respiratory Tract Infections / microbiology ; Retrospective Studies ; Young Adult
Departments: Katedra za internu medicinu
Depositing User: Martina Žužak
Status: Published
Janković, MatejaUNSPECIFIED
Katalinić Janković, VeraUNSPECIFIED
Jakopović, MarkoUNSPECIFIED
Obrovac, MihaelaUNSPECIFIED
Kardum Bulat, LjiljanaUNSPECIFIED
Popović Grle, SanjaUNSPECIFIED
Mareković, IvanaUNSPECIFIED
Samaržija, MiroslavUNSPECIFIED
van Ingen, JakkoUNSPECIFIED
Date: July 2016
Date Deposited: 01 Dec 2017 09:35
Last Modified: 11 Aug 2020 08:07
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2750

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