Persons with latent autoimmune diabetes in adults express higher dipeptidyl peptidase-4 activity compared to persons with type 2 and type 1 diabetes

Duvnjak, Lea and Blaslov, Kristina and Vučić Lovrenčić, Marijana and Knežević Ćuća, Jadranka (2016) Persons with latent autoimmune diabetes in adults express higher dipeptidyl peptidase-4 activity compared to persons with type 2 and type 1 diabetes. Diabetes Research and Clinical Practice, 121. pp. 119-126. ISSN 0168-8227

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Abstract

AIMS: We aimed to determine serum dipeptidyl peptidase-4 (DPP-4) activity in a group of persons with latent autoimmune diabetes in adults (LADA) and to compare it with persons with type 1, type 2 diabetes and healthy controls. ----- METHODS: DPP-4 activity measurement was performed in 67 persons (21 with type 1, 26 type 2 and 19 with LADA) and 13 healthy age and gender matched controls. ----- RESULTS: Persons with LADA showed highest DPP-4 activity among the study groups (32.71±3.55 vs 25.37±2.84 vs 18.57±2.54 vs 18.57±2.61U/L p<0.001). Mean glutamic acid autoantibody in persons with LADA was 164.32±86.28IU/mL. It correlated with DPP-4 activity (r=0.484, p=0.013). Furthermore, DPP-4 activity correlated with waist circumference (r=0.279, p=0.034) and glycated haemoglobin A1c (r=0.483, p<0.001), as well as with LDL cholesterol (r=0.854, p<0.001) and total daily insulin dose (r=0.397, p=0.001). In the multinomial regression analysis DPP-4 activity remained associated with both LADA (prevalence ratio 1.058 (1.012-1.287), p=0.001) and type 1 diabetes (prevalence ratio 1.506 (1.335-1.765), p<0.001) while it did not show an association with type 2 diabetes (prevalence ratio 0.942 (0.713-1.988), p=0.564). ----- CONCLUSIONS: Persons with LADA express higher DPP-4 activity compared to persons with both type 1 and type 2 diabetes. The possible pathophysiological role of DPP-4 in the LADA pathogenesis needs to be further evaluated.

Item Type: Article
MeSH: Adult ; Autoantibodies/blood ; Biomarkers/blood ; Diabetes Mellitus, Type 1/enzymology ; Diabetes Mellitus, Type 2/enzymology ; Dipeptidyl Peptidase 4/blood ; Female ; Hemoglobin A, Glycosylated/metabolism ; Humans ; Latent Autoimmune Diabetes in Adults/enzymology ; Male ; Middle Aged
Departments: Katedra za internu medicinu
Depositing User: Martina Žužak
Status: Published
Creators:
CreatorsEmail
Duvnjak, LeaUNSPECIFIED
Blaslov, KristinaUNSPECIFIED
Vučić Lovrenčić, MarijanaUNSPECIFIED
Knežević Ćuća, JadrankaUNSPECIFIED
Date: November 2016
Date Deposited: 10 Nov 2017 09:50
Last Modified: 10 Aug 2020 08:54
Subjects: UNSPECIFIED
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2736

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