Correlation of the VEMP score, ambulation and upper extremity function in clinically isolated syndrome

Crnošija, Luka and Krbot Skorić, Magdalena and Gabelić, Tereza and Adamec, Ivan and Brinar, Vesna and Habek, Mario (2015) Correlation of the VEMP score, ambulation and upper extremity function in clinically isolated syndrome. Journal of the Neurological Sciences, 359 (1-2). pp. 197-201. ISSN 0022-510X

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OBJECTIVE: To investigate the correlation of the vestibular evoked myogenic potential (VEMP) score with Timed 25-Foot Walk (T25FW), 9-Hole Peg Test (9HPT), Paced Auditory Serial Addition Test (PASAT) and EDSS in patients with multiple sclerosis (MS). ----- METHODS: This prospective, cross sectional study included 52 patients with clinically isolated syndrome (CIS). Cervical VEMP (cVEMP) and ocular VEMP (oVEMP), analyzed in the form of the cVEMP, oVEMP and VEMP scores, T25FW, 9HPT, PASAT and Expanded Disability Status Scale (EDSS) were performed. ----- RESULTS: The only predictor of walking impairment in this study was general disability as measured by the EDSS, after controlling for age, gender, PASAT and EDSS the effect of VEMP score was non-significant (p=0.419). 9HPT of the dominant hand did not correlate with the oVEMP score (rs=0.258, p=0.065), however after controlling for age, gender, PASAT and EDSS, the effect of the oVEMP score on 9HPT of the dominant hand was statistically significant (p=0.017). After controlling for age, gender and oVEMP score, the effect of the PASAT on 9HPT variable for the non-dominant hand was statistically significant (p=0.001). ----- CONCLUSION: We found possible effects of brainstem dysfunction on walking impairment, however they were not seen after correction for EDSS and cognitive dysfunction. On the other hand, dominant hand function seems to be influenced by upper brainstem dysfunction measured with oVEMP, while cognitive dysfunction is related to non-dominant hand function.

Item Type: Article
MeSH: Acoustic Stimulation ; Adult ; Cross-Sectional Studies ; Electroencephalography ; Female ; Gait Disorders, Neurologic/etiology ; Humans ; Male ; Multiple Sclerosis/complications ; Prospective Studies ; Severity of Illness Index ; Statistics as Topic ; Upper Extremity/physiopathology ; Vestibular Evoked Myogenic Potentials/physiology ; Vestibule, Labyrinth/physiopathology ; Walking/physiology ; Young Adult
Departments: Katedra za neurologiju
Depositing User: Martina Žužak
Status: Published
Krbot Skorić, MagdalenaUNSPECIFIED
Gabelić, TerezaUNSPECIFIED
Date: 15 December 2015
Date Deposited: 25 Oct 2017 08:00
Last Modified: 21 Jul 2020 08:33
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