Molecular genetics of intracranial meningiomas with emphasis on canonical Wnt signalling

Pećina-Šlaus, Nives and Kafka, Anja and Lechpammer, Mirna (2016) Molecular genetics of intracranial meningiomas with emphasis on canonical Wnt signalling. Cancers, 8 (7). p. 67. ISSN 2072-6694

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Official URL: https://doi.org/10.3390/cancers8070067

Abstract

Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins in this common brain tumour, describing their known functional effects. Meningiomas originate from the meningeal layers of the brain and the spinal cord. Most meningiomas have benign clinical behaviour and are classified as grade I by World Health Organization (WHO). However, up to 20% histologically classified as atypical (grade II) or anaplastic (grade III) are associated with higher recurrent rate and have overall less favourable clinical outcome. Recently, there is emerging evidence that multiple signalling pathways including Wnt pathway contribute to the formation and growth of meningiomas. In the review we present the synopsis on meningioma histopathology and genetics and discuss our research regarding Wnt in meningioma. Epithelial-to-mesenchymal transition, a process in which Wnt signalling plays an important role, is shortly discussed.

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Article

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© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

Departments:

Hrvatski institut za istraživanje mozga
Katedra za medicinsku biologiju

Depositing User:

Martina Žužak

Status:

Published

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