Endothelial lipase plasma levels are increased in both sexes in stable coronary artery disease and only in women with acute coronary syndrome but not associated with the severity of coronary artery disease

Trbušić, Matias and Potočnjak, Ines and Tiran, Beate and Bodrožić-Džakić, Tomislava and Milošević, Milan and Degoricija, Vesna and Frank, Saša (2016) Endothelial lipase plasma levels are increased in both sexes in stable coronary artery disease and only in women with acute coronary syndrome but not associated with the severity of coronary artery disease. Croatian Medical Journal, 57 (5). pp. 482-492. ISSN 0353-9504

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Abstract

AIM: To investigate whether endothelial lipase (EL) plasma levels are increased in stable coronary artery disease (sCAD) and acute coronary syndrome (ACS) patients, as well as to test the association of EL plasma levels and the severity of CAD and sex. ----- METHODS: The study was performed as a single-center, cross-sectional, observational research on 72 sCAD and 187 ACS patients in the Sisters of Charity University Hospital Centre, Zagreb, Croatia, between December 1, 2011 and December 1, 2012. EL plasma levels were measured using ELISA. ----- RESULTS: EL plasma levels were significantly higher in sCAD patients (median 311.3 pg/mL, interquartile range [IQR] 250.4-422.6 pg/mL) than in ACS patients (median=258.7 pg/mL, IQR=162.1-356.0 pg/mL; P<0.001). EL levels in female ACS patients were significantly higher (median 314.5 pg/mL, IQR 218.3-420.8 pg/mL) than in male ACS patients (median 225.4 pg/mL, IQR 148.7320.1 pg/mL; P<0.001) and similar to the EL levels in the sCAD patients. There was no significant correlation between EL plasma levels and the GENSINI score and between EL plasma levels and the number of atherosclerotic coronary artery segments in either the ACS (rho=-0.09, P=0.247; rho=0.12, P=0.106, respectively) or sCAD group (rho=0.04, P=0.771; rho=0.06, P=0.643, respectively). ----- CONCLUSION: Our results suggest that EL plasma levels discriminate male but not female patients with different clinical presentations of CAD, as well as female and male ACS patients. EL plasma levels are not significantly correlated with CAD severity.

Abstract in Croatian

Razine endotelijalne lipaze u plazmi povišene su kod pacijenata oba spola sa stabilnom bolešću koronarnih arterija te kod žena s akutnim koronarnim sindromom, ali nisu povezane s težinom bolesti koronarnih arterija ----- Cilj: Istražiti jesu li razine endotelijalne lipaze (EL) u plazmi povišene kod pacijenata sa stabilnom bolešću koronarnih arterija i akutnim koronarnim sindromom te testirati povezanost između razina EL u plazmi i težine bolesti koronarnih arterija i spola. ----- Postupci: Ovo presječno opservacijsko istraživanje provedeno u Kliničkom bolničkom centru Sestre milosrdnice u Zagrebu između 1. prosinca 2011. i 1. prosinca 2012. uključilo je 72 pacijenta sa stabilnom bolešću korornarnih arterija i 187 pacijenata s akutnim koronarnim sindromom. Razine EL mjerene su metodom ELISA-e (prema engl. enzyme-linked immunosorbent assay). ----- Rezultati: Razine EL u plazmi bile su značajno više kod pacijenata sa stabilnom bolešću koronarnih arterija (medijan 311,3 pg/mL, interkvartilni raspon [prema engl. interquartile range, IQR] 250,4-422,6 pg/mL) nego kod pacijenata s akutnim koronarnim sindromom (258,7 pg/mL, 162,1-356,0 pg/mL; P< 0,001). Razine EL kod žena s akutnim koronarnim sindromom bile su značajno više (314,5 pg/mL, IQR 218,3-420,8 pg/mL) nego kod muškaraca s akutnim koronarnim sindromom (225,4 pg/mL, IQR 148,7320.1 pg/mL; P< 0,001), ali su bile slične razinama kod pacijenata sa stabilnom bolešću koronarnih arterija. Nije postojala značajna korelacija između razina EL i izračuna GENSINI, kao niti između razina EL i broja aterosklerotičnih segmenata korornarnih arterija niti kod pacijenata s akutnim koronarnim sindromom (rho = -0,09, P= 0,247; odnosno rho = 0,12, P= 0,106) niti kod pacijenata sa stabilnom bolešću korornarnih arterija (rho = 0,04, P= 0,771; odnosno rho = 0,06, P= 0,643). ----- Zaključak: Naši rezultati pokazuju da razine EL u plazmi mogu razlikovati muškarce ali ne i žene s različitim kliničkim manifestacijama bolesti korornarnih arterija, kao i muškarce od žena s akutnim koronarnim sindromom. Razine EL nisu značajno korelirale s težinom bolesti koronarnih arterija.

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