Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: a prospective multicentre study (WISS Study).

Sartelli, Massimo and Abu-Zidan, Fikri M. and Catena, Fausto and Griffiths, Ewen A. and Di Saverio, Salomone and Coimbra, Raul and Ordoñez, Carlos A. and Leppaniemi, Ari and Fraga, Gustavo P. and Coccolini, Federico and Agresta, Ferdinando and Abbas, Asrhaf and Abdel Kader, Saleh and Agboola, John and Amhed, Adamu and Ajibade, Adesina and Akkucuk, Seckin and Alharthi, Bandar and Anyfantakis, Dimitrios and Augustin, Goran and Baiocchi, Gianluca and Bala, Miklosh and Baraket, Oussama and Bayrak, Savas and Bellanova, Giovanni and Beltràn, Marcelo A. and Bini, Roberto and Boal, Matthew and Borodach, Andrey V. and Bouliaris, Konstantinos and Branger, Frederic and Brunelli, Daniele and Catani, Marco and Che Jusoh, Asri and Chichom-Mefire, Alain and Cocorullo, Gianfranco and Colak, Elif and Costa, David and Costa, Silvia and Cui, Yunfeng and Curca, Geanina Loredana and Curry, Terry and Das, Koray and Delibegovic, Samir and Demetrashvili, Zaza and Di Carlo, Isidoro and Drozdova, Nadezda and El Zalabany, Tamer and Enani, Mushira Abdulaziz and Faro, Mario and Gachabayov, Mahir and Giménez Maurel, Teresa and Gkiokas, Georgios and Gomes, Carlos Augusto and Gonsaga, Ricardo Alessandro Teixeira and Guercioni, Gianluca and Guner, Ali and Gupta, Sanjay and Gutierrez, Sandra and Hutan, Martin and Ioannidis, Orestis and Isik, Arda and Izawa, Yoshimitsu and Jain, Sumita A. and Jokubauskas, Mantas and Karamarkovic, Aleksandar and Kauhanen, Saila and Kaushik, Robin and Kenig, Jakub and Khokha, Vladimir and Kim, Jae Il and Kong, Victor and Koshy, Renol and Krasniqi, Avidyl and Kshirsagar, Ashok and Kuliesius, Zygimantas and Lasithiotakis, Konstantinos and Leão, Pedro and Lee, Jae Gil and Leon, Miguel and Lizarazu Pérez, Aintzane and Lohsiriwat, Varut and López-Tomassetti Fernandez, Eudaldo and Lostoridis, Eftychios and Mn, Raghuveer and Major, Piotr and Marinis, Athanasios and Marrelli, Daniele and Martinez-Perez, Aleix and Marwah, Sanjay and McFarlane, Michael and Melo, Renato Bessa and Mesina, Cristian and Michalopoulos, Nick and Moldovanu, Radu and Mouaqit, Ouadii and Munyika, Akutu and Negoi, Ionut and Nikolopoulos, Ioannis and Nita, Gabriela Elisa and Olaoye, Iyiade and Omari, Abdelkarim and Ossa, Paola Rodríguez and Ozkan, Zeynep and Padmakumar, Ramakrishnapillai and Pata, Francesco and Pereira Junior, Gerson Alves and Pereira, Jorge and Pintar, Tadeja and Pouggouras, Konstantinos and Prabhu, Vinod and Rausei, Stefano and Rems, Miran and Rios-Cruz, Daniel and Sakakushev, Boris and Sánchez de Molina, Maria Luisa and Seretis, Charampolos and Shelat, Vishal and Simões, Romeo Lages and Sinibaldi, Giovanni and Skrovina, Matej and Smirnov, Dmitry and Spyropoulos, Charalampos and Tepp, Jaan and Tezcaner, Tugan and Tolonen, Matti and Torba, Myftar and Ulrych, Jan and Uzunoglu, Mustafa Yener and van Dellen, David and van Ramshorst, Gabrielle H. and Vasquez, Giorgio and Venara, Aurélien and Vereczkei, Andras and Vettoretto, Nereo and Vlad, Nutu and Yadav, Sanjay Kumar and Yilmaz, Tonguç Utku and Yuan, Kuo-Ching and Zachariah, Sanoop Koshy and Zida, Maurice and Zilinskas, Justas and Ansaloni, Luca (2015) Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: a prospective multicentre study (WISS Study). World Journal of Emergency Surgery, 10. p. 61. ISSN 1749-7922

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Abstract

BACKGROUND: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. ----- METHODS: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2 years (range 18-99) were enrolled in the WISS study. ----- RESULTS: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2 %, a specificity of 83.5 % and a positive likelihood ratio of 5.4. ----- CONCLUSIONS: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.

Item Type: Article
Additional Information: © 2015 Sartelli et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0) applies to the data made available in this article, unless otherwise stated.
Departments: Katedra za kirurgiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Sartelli, MassimoUNSPECIFIED
Abu-Zidan, Fikri M.UNSPECIFIED
Catena, FaustoUNSPECIFIED
Griffiths, Ewen A.UNSPECIFIED
Di Saverio, SalomoneUNSPECIFIED
Coimbra, RaulUNSPECIFIED
Ordoñez, Carlos A.UNSPECIFIED
Leppaniemi, AriUNSPECIFIED
Fraga, Gustavo P.UNSPECIFIED
Coccolini, FedericoUNSPECIFIED
Agresta, FerdinandoUNSPECIFIED
Abbas, AsrhafUNSPECIFIED
Abdel Kader, SalehUNSPECIFIED
Agboola, JohnUNSPECIFIED
Amhed, AdamuUNSPECIFIED
Ajibade, AdesinaUNSPECIFIED
Akkucuk, SeckinUNSPECIFIED
Alharthi, BandarUNSPECIFIED
Anyfantakis, DimitriosUNSPECIFIED
Augustin, GoranUNSPECIFIED
Baiocchi, GianlucaUNSPECIFIED
Bala, MikloshUNSPECIFIED
Baraket, OussamaUNSPECIFIED
Bayrak, SavasUNSPECIFIED
Bellanova, GiovanniUNSPECIFIED
Beltràn, Marcelo A.UNSPECIFIED
Bini, RobertoUNSPECIFIED
Boal, MatthewUNSPECIFIED
Borodach, Andrey V.UNSPECIFIED
Bouliaris, KonstantinosUNSPECIFIED
Branger, FredericUNSPECIFIED
Brunelli, DanieleUNSPECIFIED
Catani, MarcoUNSPECIFIED
Che Jusoh, AsriUNSPECIFIED
Chichom-Mefire, AlainUNSPECIFIED
Cocorullo, GianfrancoUNSPECIFIED
Colak, ElifUNSPECIFIED
Costa, DavidUNSPECIFIED
Costa, SilviaUNSPECIFIED
Cui, YunfengUNSPECIFIED
Curca, Geanina LoredanaUNSPECIFIED
Curry, TerryUNSPECIFIED
Das, KorayUNSPECIFIED
Delibegovic, SamirUNSPECIFIED
Demetrashvili, ZazaUNSPECIFIED
Di Carlo, IsidoroUNSPECIFIED
Drozdova, NadezdaUNSPECIFIED
El Zalabany, TamerUNSPECIFIED
Enani, Mushira AbdulazizUNSPECIFIED
Faro, MarioUNSPECIFIED
Gachabayov, MahirUNSPECIFIED
Giménez Maurel, TeresaUNSPECIFIED
Gkiokas, GeorgiosUNSPECIFIED
Gomes, Carlos AugustoUNSPECIFIED
Gonsaga, Ricardo Alessandro TeixeiraUNSPECIFIED
Guercioni, GianlucaUNSPECIFIED
Guner, AliUNSPECIFIED
Gupta, SanjayUNSPECIFIED
Gutierrez, SandraUNSPECIFIED
Hutan, MartinUNSPECIFIED
Ioannidis, OrestisUNSPECIFIED
Isik, ArdaUNSPECIFIED
Izawa, YoshimitsuUNSPECIFIED
Jain, Sumita A.UNSPECIFIED
Jokubauskas, MantasUNSPECIFIED
Karamarkovic, AleksandarUNSPECIFIED
Kauhanen, SailaUNSPECIFIED
Kaushik, RobinUNSPECIFIED
Kenig, JakubUNSPECIFIED
Khokha, VladimirUNSPECIFIED
Kim, Jae IlUNSPECIFIED
Kong, VictorUNSPECIFIED
Koshy, RenolUNSPECIFIED
Krasniqi, AvidylUNSPECIFIED
Kshirsagar, AshokUNSPECIFIED
Kuliesius, ZygimantasUNSPECIFIED
Lasithiotakis, KonstantinosUNSPECIFIED
Leão, PedroUNSPECIFIED
Lee, Jae GilUNSPECIFIED
Leon, MiguelUNSPECIFIED
Lizarazu Pérez, AintzaneUNSPECIFIED
Lohsiriwat, VarutUNSPECIFIED
López-Tomassetti Fernandez, EudaldoUNSPECIFIED
Lostoridis, EftychiosUNSPECIFIED
Mn, RaghuveerUNSPECIFIED
Major, PiotrUNSPECIFIED
Marinis, AthanasiosUNSPECIFIED
Marrelli, DanieleUNSPECIFIED
Martinez-Perez, AleixUNSPECIFIED
Marwah, SanjayUNSPECIFIED
McFarlane, MichaelUNSPECIFIED
Melo, Renato BessaUNSPECIFIED
Mesina, CristianUNSPECIFIED
Michalopoulos, NickUNSPECIFIED
Moldovanu, RaduUNSPECIFIED
Mouaqit, OuadiiUNSPECIFIED
Munyika, AkutuUNSPECIFIED
Negoi, IonutUNSPECIFIED
Nikolopoulos, IoannisUNSPECIFIED
Nita, Gabriela ElisaUNSPECIFIED
Olaoye, IyiadeUNSPECIFIED
Omari, AbdelkarimUNSPECIFIED
Ossa, Paola RodríguezUNSPECIFIED
Ozkan, ZeynepUNSPECIFIED
Padmakumar, RamakrishnapillaiUNSPECIFIED
Pata, FrancescoUNSPECIFIED
Pereira Junior, Gerson AlvesUNSPECIFIED
Pereira, JorgeUNSPECIFIED
Pintar, TadejaUNSPECIFIED
Pouggouras, KonstantinosUNSPECIFIED
Prabhu, VinodUNSPECIFIED
Rausei, StefanoUNSPECIFIED
Rems, MiranUNSPECIFIED
Rios-Cruz, DanielUNSPECIFIED
Sakakushev, BorisUNSPECIFIED
Sánchez de Molina, Maria LuisaUNSPECIFIED
Seretis, CharampolosUNSPECIFIED
Shelat, VishalUNSPECIFIED
Simões, Romeo LagesUNSPECIFIED
Sinibaldi, GiovanniUNSPECIFIED
Skrovina, MatejUNSPECIFIED
Smirnov, DmitryUNSPECIFIED
Spyropoulos, CharalamposUNSPECIFIED
Tepp, JaanUNSPECIFIED
Tezcaner, TuganUNSPECIFIED
Tolonen, MattiUNSPECIFIED
Torba, MyftarUNSPECIFIED
Ulrych, JanUNSPECIFIED
Uzunoglu, Mustafa YenerUNSPECIFIED
van Dellen, DavidUNSPECIFIED
van Ramshorst, Gabrielle H.UNSPECIFIED
Vasquez, GiorgioUNSPECIFIED
Venara, AurélienUNSPECIFIED
Vereczkei, AndrasUNSPECIFIED
Vettoretto, NereoUNSPECIFIED
Vlad, NutuUNSPECIFIED
Yadav, Sanjay KumarUNSPECIFIED
Yilmaz, Tonguç UtkuUNSPECIFIED
Yuan, Kuo-ChingUNSPECIFIED
Zachariah, Sanoop KoshyUNSPECIFIED
Zida, MauriceUNSPECIFIED
Zilinskas, JustasUNSPECIFIED
Ansaloni, LucaUNSPECIFIED
Date: 16 December 2015
Date Deposited: 08 Aug 2016 11:45
Last Modified: 08 Aug 2016 11:45
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2620

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