Duvnjak, Lea and Blaslov, Kristina (2016) Dipeptidyl peptidase-4 inhibitors improve arterial stiffness, blood pressure, lipid profile and inflammation parameters in patients with type 2 diabetes mellitus. Diabetology & Metabolic Syndrome, 8. p. 26. ISSN 1758-5996
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Abstract
BACKGROUND: This uncontrolled open label study evaluated the effect of dipeptidyl peptidase-4 inhibitors (DPP-4i): sitagliptin and vildagliptin on augmentation index standardized for 75 beats per minute (cAiX@75), blood pressure (BP), lipid profile and high-sensitivity C-reactive protein (hsCRP) in patients with type 2 diabetes mellitus (T2DM). ----- METHODS: Fifty-one well-regulated T2DM patients were randomly assigned to either sitagliptin or vildagliptin (100 mg/day) for 3 months continuing their previous treatment. Lipid profile, cAiX@75, hsCRP, glycated hemoglobin (HbA1c) were measured at baseline at 4, 8 and 12th week were accessed. cAiX@75 and pulse wave velocity (PWV) were determined by SphygmoCor device. ----- RESULTS: Following DPP-4 treatment there was a significant reduction in total serum cholesterol (5.18 vs 4.62 mmol/L), low-density lipoprotein (2.89 vs 2.54 mmol/L), hsCRP (3.21 vs 1.95 mg/L), cAiX@75 (24.5 vs 22.3) and central systolic BP (131.8 vs 119.5 mmHg). The sitagliptin treated group reached cAiX@75 reduction earlier in the study period while neither sitagliptin or vildagliptin use resulted in the significant HbA1c reduction. ----- CONCLUSION: The treatment with DPP-4i: sitagliptin and vildagliptin provides favorable metabolic and vascular effects beyond glucose-control. Further studies are required to elucidate their implication in metabolic pathways.
| Item Type: | Article | ||||||
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| Additional Information: | © 2016 Duvnjak and Blaslov. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons. org/publicdomain/zero/1.0) applies to the data made available in this article, unless otherwise stated. | ||||||
| Departments: | Katedra za internu medicinu | ||||||
| Depositing User: | Marijan Šember | ||||||
| Status: | Published | ||||||
| Creators: |
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| Date: | 22 March 2016 | ||||||
| Date Deposited: | 04 Aug 2016 08:21 | ||||||
| Last Modified: | 10 Aug 2020 08:47 | ||||||
| Subjects: | / | ||||||
| Related URLs: | |||||||
| URI: | http://medlib.mef.hr/id/eprint/2615 |
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