Modulating composition and metabolic activity of the gut microbiota in IBD patients

Matijašić, Mario and Meštrović, Tomislav and Perić, Mihaela and Čipčić Paljetak, Hana and Panek, Marina and Vranešić Bender, Darija and Ljubas Kelečić, Dina and Krznarić, Željko and Verbanac, Donatella (2016) Modulating composition and metabolic activity of the gut microbiota in IBD patients. International Journal of Molecular Sciences, 17 (4). p. 578. ISSN 1422-0067

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The healthy intestine represents a remarkable interface where sterile host tissues come in contact with gut microbiota, in a balanced state of homeostasis. The imbalance of gut homeostasis is associated with the onset of many severe pathological conditions, such as inflammatory bowel disease (IBD), a chronic gastrointestinal disorder increasing in incidence and severely influencing affected individuals. Despite the recent development of next generation sequencing and bioinformatics, the current scientific knowledge of specific triggers and diagnostic markers to improve interventional approaches in IBD is still scarce. In this review we present and discuss currently available and emerging therapeutic options in modulating composition and metabolic activity of gut microbiota in patients affected by IBD. Therapeutic approaches at the microbiota level, such as dietary interventions alone or with probiotics, prebiotics and synbiotics, administration of antibiotics, performing fecal microbiota transplantation (FMT) and the use of nematodes, all represent a promising opportunities towards establishing and maintaining of well-being as well as improving underlying IBD symptoms.

Item Type: Article
Additional Information: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (
MeSH: Animals ; Anti-Bacterial Agents / therapeutic use ; Diet ; Fecal Microbiota Transplantation ; Gastrointestinal Microbiome ; Helminths / physiology ; Homeostasis ; Humans ; Inflammatory Bowel Diseases / microbiology ; Inflammatory Bowel Diseases / parasitology ; Inflammatory Bowel Diseases / therapy ; Nutritional Physiological Phenomena ; Prebiotics ; Probiotics / therapeutic use ; Synbiotics
Departments: Katedra za internu medicinu
Depositing User: Marijan Šember
Status: Published
Matijašić, MarioUNSPECIFIED
Meštrović, TomislavUNSPECIFIED
Čipčić Paljetak, HanaUNSPECIFIED
Vranešić Bender, DarijaUNSPECIFIED
Ljubas Kelečić, DinaUNSPECIFIED
Krznarić, ŽeljkoUNSPECIFIED
Verbanac, DonatellaUNSPECIFIED
Date: 19 April 2016
Date Deposited: 23 May 2016 12:32
Last Modified: 12 Aug 2020 06:50
Subjects: /
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