Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Thrombotic microangiopathy associated with alpha-interferon therapy for chronic myeloid leukaemia

Galešić, Krešimir and Božić, Borka and Račić, Ivana and Šćukanec-Špoljar, Mira (2006) Thrombotic microangiopathy associated with alpha-interferon therapy for chronic myeloid leukaemia. Nephrology, 11 (1). pp. 49-52. ISSN 1320-5358 (Print) 1440-1797 (Electronic)

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    English abstract

    The association of interferon (IFN) therapy with haemolytic uraemic syndrome in patients with chronic myeloid leukaemia (CML) has been reported infrequently. The pathogenesis of the renal lesion in such cases remains unclear. We report the case of a patient with chronic myeloid leukaemia who developed nephrotic syndrome and renal failure while being treated with hydroxyurea and IFN-α. Renal biopsy showed features of chronic thrombotic microangiopathy. The discontinuation of IFN-α, and a prompt institution of plasmapheresis and steroids resulted in improvement of the nephrotic syndrome and renal function. These findings suggest that long-term IFN-α therapy can induce thrombotic microangiopathy and haemolytic uraemic syndrome in patients with chronic myeloid leukaemia.

    Item Type: Article
    MeSH: Antineoplastic Agents - adverse effects - therapeutic use ; Hemolytic-Uremic Syndrome - chemically induced ; Interferon-alpha - adverse effects - therapeutic use ; Kidney Failure - chemically induced ; Leukemia, Myeloid, Chronic - drug therapy ; Nephrotic Syndrome - chemically induced ; Humans ; Male ; Middle Aged
    Divisions: Katedra za internu medicinu
    Katedra za patologiju
    Depositing User: Lea Škorić
    Status: Published
    Creators:
    CreatorsEmail
    Galešić, Krešimir
    Božić, Borka
    Račić, Ivana
    Šćukanec-Špoljar, Mira
    Date: February 2006
    Date Deposited: 12 Apr 2007
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/258

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