A new look at cerebrospinal fluid movement

Orešković, Darko and Klarica, Marijan (2014) A new look at cerebrospinal fluid movement. Fluids and Barriers of the CNS, 11. p. 16. ISSN 2045-8118

[img] PDF - Published Version
Download (240kB)


Brinker et al. extensively reviewed recent findings about CSF circulation in a recent article: "A new look at cerebrospinal circulation", but did not analyze some important available data in sufficient detail. For example, our findings as well as some clinical data and experimental results obtained from different animal species, do not support unidirectional CSF circulation but strongly suggest that there are cardiac cycle-dependent systolic-diastolic to-and-fro cranio-spinal CSF movements. These are based on: a) physiological oscillations of arterial and venous blood during cranio-spinal blood circulation; b) respiratory activity, and c) body activity and posture. That kind of complex CSF movement could explain the observed distribution of many different substances in all directions along the CSF system and within central nervous system tissue. It seems that efflux transport systems at capillary endothelium may be more important for brain homeostasis than the removal of metabolites by CSF flow. Thus, when discussing the CSF dynamics we suggest that a more appropriate term would be CSF movement rather than CSF circulation.

Item Type: Article
Additional Information: © Orešković and Klarica; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​4.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0​) applies to the data made available in this article, unless otherwise stated.
Departments: Katedra za farmakologiju
Depositing User: Marijan Šember
Status: Published
Orešković, DarkoUNSPECIFIED
Klarica, MarijanUNSPECIFIED
Date: 27 July 2014
Date Deposited: 31 Mar 2016 10:47
Last Modified: 17 Jul 2020 10:04
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2566

Actions (login required)

View Item View Item


Downloads per month over past year