Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an IPD meta-analysis.

Muthuri, Stella G. and Venkatesan, Sudhir and Myles, Puja R. and Leonardi-Bee, Jo and Lim, Wei Shen and Mamun, Abdullah Al and Anovadiya, Ashish P. and Araújo, Wildo N. and Azziz-Baumgartner, Eduardo and Báez, Clarisa and Bantar, Carlos and Barhoush, Mazen M. and Bassetti, Matteo and Beović, Bojana and Bingisser, Roland and Bonmarin, Isabelle and Borja-Aburto, Victor H. and Cao, Bin and Carratala, Jordi and Cuezzo, María R. and Denholm, Justin T. and Dominguez, Samuel R. and Duarte, Pericles A. D. and Dubnov-Raz, Gal and Echavarria, Marcela and Fanella, Sergio and Fraser, James and Gao, Zhancheng and Gérardin, Patrick and Giannella, Maddalena and Gubbels, Sophie and Herberg, Jethro and Higuera Iglesias, Anjarath L. and Hoeger, Peter H. and Hoffmann, Matthias and Hu, Xiaoyun and Islam, Quazi T. and Jiménez, Mirela F. and Kandeel, Amr and Keijzers, Gerben and Khalili, Hossein and Khandaker, Gulam and Knight, Marian and Kusznierz, Gabriela and Kuzman, Ilija and Kwan, Arthur M. C. and Lahlou Amine, Idriss and Langenegger, Eduard and Lankarani, Kamran B. and Leo, Yee-Sin and Linko, Rita and Liu, Pei and Madanat, Faris and Manabe, Toshie and Mayo-Montero, Elga and McGeer, Allison and Memish, Ziad A. and Metan, Gokhan and Mikić, Dragan and Mohn, Kristin G. I. and Moradi, Ahmadreza and Nymadawa, Pagbajabyn and Ozbay, Bulent and Ozkan, Mehpare and Parekh, Dhruv and Paul, Mical and Poeppl, Wolfgang and Polack, Fernando P. and Rath, Barbara A. and Rodríguez, Alejandro H. and Siqueira, Marilda M. and Skręt-Magierło, Joanna and Talarek, Ewa and Tang, Julian W. and Torres, Antoni and Törün, Selda H. and Tran, Dat and Uyeki, Timothy M. and van Zwol, Annelies and Vaudry, Wendy and Velyvyte, Daiva and Vidmar, Tjasa and Zarogoulidis, Paul and Nguyen-Van-Tam, Jonathan S. (2015) Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an IPD meta-analysis. Influenza and Other Respiratory Viruses, Epub a. ISSN 1750-2640

[img] PDF
Download (336kB)

Abstract

BACKGROUND: The impact of neuraminidase inhibitors (NAIs) on Influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. ----- METHODS: A worldwide meta-analysis of individual participant data (IPD) from 20,634 hospitalised patients with laboratory confirmed A(H1N1)pdm09 (n=20,021) or clinically diagnosed (n=613) 'pandemic influenza'. The primary outcome was radiologically confirmed influenza-related pneumonia (IRP). Odds ratios (OR) were estimated using generalized linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids. ----- RESULTS: Among 20,634 included participants, 5,978 (29.0%) had IRP; conversely, 3,349 (16.2%) had confirmed absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0.83 (95%CI 0.64 - 1.06; p=0.136)]. Among the 5,978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR=0.72 (0.44-1.17; p=0.180)] or likelihood of requiring ventilatory support [adj. OR=1.17 (0.71-1.92; p=0.537)]; but early treatment versus later significantly reduced mortality [adj. OR=0.70 (0.55-0.88; p=0.003)] and likelihood of requiring ventilatory support [adj. OR=0.68 (0.54-0.85; p=0.001)]. ----- CONCLUSIONS: Early NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support.

Item Type: Article
Additional Information: © 2015 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Departments: Katedra za infektologiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Muthuri, Stella G.UNSPECIFIED
Venkatesan, SudhirUNSPECIFIED
Myles, Puja R.UNSPECIFIED
Leonardi-Bee, JoUNSPECIFIED
Lim, Wei ShenUNSPECIFIED
Mamun, Abdullah AlUNSPECIFIED
Anovadiya, Ashish P.UNSPECIFIED
Araújo, Wildo N.UNSPECIFIED
Azziz-Baumgartner, EduardoUNSPECIFIED
Báez, ClarisaUNSPECIFIED
Bantar, CarlosUNSPECIFIED
Barhoush, Mazen M.UNSPECIFIED
Bassetti, MatteoUNSPECIFIED
Beović, BojanaUNSPECIFIED
Bingisser, RolandUNSPECIFIED
Bonmarin, IsabelleUNSPECIFIED
Borja-Aburto, Victor H.UNSPECIFIED
Cao, BinUNSPECIFIED
Carratala, JordiUNSPECIFIED
Cuezzo, María R.UNSPECIFIED
Denholm, Justin T.UNSPECIFIED
Dominguez, Samuel R.UNSPECIFIED
Duarte, Pericles A. D.UNSPECIFIED
Dubnov-Raz, GalUNSPECIFIED
Echavarria, MarcelaUNSPECIFIED
Fanella, SergioUNSPECIFIED
Fraser, JamesUNSPECIFIED
Gao, ZhanchengUNSPECIFIED
Gérardin, PatrickUNSPECIFIED
Giannella, MaddalenaUNSPECIFIED
Gubbels, SophieUNSPECIFIED
Herberg, JethroUNSPECIFIED
Higuera Iglesias, Anjarath L.UNSPECIFIED
Hoeger, Peter H.UNSPECIFIED
Hoffmann, MatthiasUNSPECIFIED
Hu, XiaoyunUNSPECIFIED
Islam, Quazi T.UNSPECIFIED
Jiménez, Mirela F.UNSPECIFIED
Kandeel, AmrUNSPECIFIED
Keijzers, GerbenUNSPECIFIED
Khalili, HosseinUNSPECIFIED
Khandaker, GulamUNSPECIFIED
Knight, MarianUNSPECIFIED
Kusznierz, GabrielaUNSPECIFIED
Kuzman, IlijaUNSPECIFIED
Kwan, Arthur M. C.UNSPECIFIED
Lahlou Amine, IdrissUNSPECIFIED
Langenegger, EduardUNSPECIFIED
Lankarani, Kamran B.UNSPECIFIED
Leo, Yee-SinUNSPECIFIED
Linko, RitaUNSPECIFIED
Liu, PeiUNSPECIFIED
Madanat, FarisUNSPECIFIED
Manabe, ToshieUNSPECIFIED
Mayo-Montero, ElgaUNSPECIFIED
McGeer, AllisonUNSPECIFIED
Memish, Ziad A.UNSPECIFIED
Metan, GokhanUNSPECIFIED
Mikić, DraganUNSPECIFIED
Mohn, Kristin G. I.UNSPECIFIED
Moradi, AhmadrezaUNSPECIFIED
Nymadawa, PagbajabynUNSPECIFIED
Ozbay, BulentUNSPECIFIED
Ozkan, MehpareUNSPECIFIED
Parekh, DhruvUNSPECIFIED
Paul, MicalUNSPECIFIED
Poeppl, WolfgangUNSPECIFIED
Polack, Fernando P.UNSPECIFIED
Rath, Barbara A.UNSPECIFIED
Rodríguez, Alejandro H.UNSPECIFIED
Siqueira, Marilda M.UNSPECIFIED
Skręt-Magierło, JoannaUNSPECIFIED
Talarek, EwaUNSPECIFIED
Tang, Julian W.UNSPECIFIED
Torres, AntoniUNSPECIFIED
Törün, Selda H.UNSPECIFIED
Tran, DatUNSPECIFIED
Uyeki, Timothy M.UNSPECIFIED
van Zwol, AnneliesUNSPECIFIED
Vaudry, WendyUNSPECIFIED
Velyvyte, DaivaUNSPECIFIED
Vidmar, TjasaUNSPECIFIED
Zarogoulidis, PaulUNSPECIFIED
Nguyen-Van-Tam, Jonathan S.UNSPECIFIED
Date: 25 November 2015
Date Deposited: 14 Mar 2016 10:57
Last Modified: 14 Mar 2016 10:57
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2550

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year