Effect of extra virgin olive oil on biomarkers of inflammation in HIV-infected patients: a randomized, crossover, controlled clinical trial

Kozić Dokmanović, Sanja and Kolovrat, Krunoslava and Laškaj, Renata and Jukić, Vedrana and Vrkić, Nada and Begovac, Josip (2015) Effect of extra virgin olive oil on biomarkers of inflammation in HIV-infected patients: a randomized, crossover, controlled clinical trial. Medical Science Monitor, 21. pp. 2406-2413. ISSN 1643-3750

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BACKGROUND: Premature atherosclerosis in HIV-infected patients is associated with chronic infection by itself and adverse effects of antiretroviral treatment (ART). Extra virgin olive oil (EVOO) has a beneficial effect on the cardiovascular system because of its anti-inflammatory properties. The objective of this study was to determine whether the consumption of EVOO improves inflammation and atherosclerosis biomarkers in HIV-infected patients receiving ART. ----- MATERIAL AND METHODS: This randomized, crossover, controlled trial included 39 HIV-positive male participants who consumed 50 mL of EVOO or refined olive oil (ROO) daily. Four participants dropped out of the study. Leukocyte count, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hsCRP), interleukin-6, fibrinogen, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, malondialdehyde, glutathione-peroxidase, superoxide dismutase, oxidized LDL and von Willebrand factor were determined before the first and after each of the 2 intervention periods. Intervention and washout periods lasted for 20 and 14 days, respectively. ----- RESULTS: In participants with >90% compliance (N=30), hsCRP concentrations were lower after EVOO intervention (geometric mean [GM], 1.70 mg/L; 95% confidence interval [CI], 1.15-2.52) compared to ROO administration (GM, 2.92 mg/L; 95% CI, 1.95-4.37) (p=0.035). In participants using lopinavir/ritonavir, ESR and hsCRP concentrations decreased 62% and 151%, respectively, after EVOO administration. In the whole study population (N=35) we found no difference in analyzed biomarkers after EVOO administration. ----- CONCLUSIONS: Our exploratory study suggests that EVOO consumption could lower hsCRP in patients on ART.

Item Type: Article
Additional Information: Copyright by International Scientific Information 2002 - 2016. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
MeSH: Adolescent ; Adult ; Aged ; Antiretroviral Therapy, Highly Active ; Atherosclerosis / blood ; Atherosclerosis / prevention & control ; Biomarkers / blood ; C-Reactive Protein / metabolism ; Cross-Over Studies ; Drug Combinations ; Food Handling ; HIV Infections / blood ; HIV Infections / diet therapy ; HIV Infections / drug therapy ; HIV Protease Inhibitors / therapeutic use ; Humans ; Inflammation Mediators / blood ; Lopinavir / therapeutic use ; Male ; Middle Aged ; Olive Oil / administration & dosage ; Olive Oil / isolation & purification ; Ritonavir / therapeutic use ; Single-Blind Method ; Young Adult
Departments: Katedra za infektologiju
Depositing User: Marijan Šember
Status: Published
Kozić Dokmanović, SanjaUNSPECIFIED
Kolovrat, KrunoslavaUNSPECIFIED
Date: 2015
Date Deposited: 11 Mar 2016 10:52
Last Modified: 23 Jul 2020 07:34
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2548

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