Familial adenomatous polyposis in three generations of a single family: a case study.

Murgić, Jure and Kirac, Iva and Soldić, Željko and Tomas, Davor and Zovak, Mario and Bolanča, Ante and Plawski, Andrzej and Banasiewicz, Tomasz and Kusić, Zvonko (2014) Familial adenomatous polyposis in three generations of a single family: a case study. Case Reports in Oncology, 7 (2). pp. 349-56. ISSN 1662-6575

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Abstract

BACKGROUND: Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited syndrome characterized by the development of numerous polyps in the colon and rectum. If left untreated, the affected patients inevitably develop colon cancer by the age of 40 years. A resection of the colon (colectomy) or of the colon and rectum (proctocolectomy) is needed to minimize the risk of cancer. ----- CASE PRESENTATION: We report a case of FAP through three generations of a single family, in which the grandmother and granddaughter underwent total colectomy with ileoanal anastomosis and did not develop colon cancer, while the son underwent subtotal colectomy with ileorectal anastomosis and developed recurrent rectal cancer. Data regarding timely surgery, surveillance, and chemoprevention are discussed. ----- CONCLUSION: The FAP phenotype determines the type of treatment. In severe polyposis, proctocolectomy with ileoanal anastomosis seems to be the optimal method for minimizing the risk of cancer development. This case report advocates complete rectal removal, especially in cases of poor patient compliance with colonoscopic surveillance.

Item Type: Article
Additional Information: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Departments: Katedra za radiologiju i opću kliničku onkologiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Murgić, JureUNSPECIFIED
Kirac, IvaUNSPECIFIED
Soldić, ŽeljkoUNSPECIFIED
Tomas, DavorUNSPECIFIED
Zovak, MarioUNSPECIFIED
Bolanča, AnteUNSPECIFIED
Plawski, AndrzejUNSPECIFIED
Banasiewicz, TomaszUNSPECIFIED
Kusić, ZvonkoUNSPECIFIED
Date: 28 May 2014
Date Deposited: 25 Feb 2016 12:38
Last Modified: 25 Feb 2016 12:38
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2508

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