Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Clinical analysis of propofol deep sedation for 1,104 patients undergoing gastrointestinal endoscopic procedures: A three year prospective study

Gašparović, Stojanka and Rustemović, Nadan and Opačić, Milorad and Premužić, Marina and Korušić, Anđelko and Božikov, Jadranka and Bates, Tamara (2006) Clinical analysis of propofol deep sedation for 1,104 patients undergoing gastrointestinal endoscopic procedures: A three year prospective study. World journal of gastroenterology, 12 (2). pp. 327-330. ISSN 1007-9327

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    English abstract

    AIM: To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy. - - - - - METHODS: In this prospective study, conducted over a period of three years, 1,104 patients referred for a same day GI endoscopy procedure were analyzed. All patients were given a propofol bolus (0.5-1.5 mg/kg). Arterial blood pressure (BP) was monitored at 3 min intervals and heart rate and oxygen saturation (SpO2) were recorded continuously by pulse oximetry. Analyzed data acquisition was carried out before, during, and after the procedure. - - - - - RESULTS: A statistically significant reduction in mean arterial pressure was demonstrated (P<0.001) when compared to pre-intervention values, but severe hypotension, defined as a systolic blood pressure below 60 mmHg, was noted in only 5 patients (0.5%). Oxygen saturation decreased from 96.5% to 94.4 % (P<0.001). A critical decrease in oxygen saturation (<90%) was documented in 27 patients (2.4%). - - - - - CONCLUSION: Our results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant hemodynamic side effects if carefully titrated. All the patients (and especially ASA III group) require monitoring and care of an anesthesiologist.

    Item Type: Article
    MeSH: Conscious Sedation ; Endoscopy, Gastrointestinal ; Hypnotics and Sedatives - pharmacology ; Propofol - pharmacology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Blood Pressure - drug effects ; Female ; Heart Rate - drug effects ; Humans ; Male ; Middle Aged ; Oxygen - blood ; Prospective Studies
    Divisions: Katedra za internu medicinu
    Depositing User: Lea Škorić
    Status: Published
    Creators:
    CreatorsEmail
    Gašparović, Stojanka
    Rustemović, Nadan
    Opačić, Milorad
    Premužić, Marina
    Korušić, Anđelko
    Božikov, Jadranka
    Bates, Tamara
    Date: 14 January 2006
    Date Deposited: 19 Mar 2007
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/247

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