Evaluation of sentinel node biopsy in oral carcinomas [Evaluacija sentinel biopsije limfnih čvorova u oralnom karcinomu]

Milenović, Aleksandar and Virag, Mišo and Knežević, Predrag and Vučićević Boras, Vanja and Trutin Ostović, Karmen and Gabrić Pandurić, Dragana and Sušić, Mato (2014) Evaluation of sentinel node biopsy in oral carcinomas [Evaluacija sentinel biopsije limfnih čvorova u oralnom karcinomu]. Collegium Antropologicum, 38 (1). pp. 279-282. ISSN 0350-6134

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Abstract

It is still a matter of debate whether sentinel node biopsy might replace neck dissection in patients with clinically negative neck lymph nodes who suffer from oral squamous cell carcinoma. In 30 patients (26 male, 4 female, average age 59.4 years) with oral squamous cell carcinoma we performed ultrasound guided punction of the lymph nodes which were lymphoscintigraphically seen together with histopatological analysis of the dissected node. Sentinel lymph node was seen in 93% cases. By use of lymphoscintigraphy sentinel node was verified in 23 patients. Ultrasound guided punction showed presence of regional disease in 10% of cases, whereas sentinel biopsy revealed 23 of the converted necks. Histopathological findings were positive in 33% of our patients. The results of this study revealed that sentinel biopsy did not reveal 27% of the patients with positive neck histopathology. In conclusion, sentinel node biopsy should be performed in selective cases as in some localizations it is easier to perform neck dissection in comparison to the sentinel node biopsy.

Abstract in Croatian

Još uvijek nije poznato da li sentinel biopsija limfnih čvorova može zamijeniti disekciju vrata u bolesnika koji boluju od karcinoma usne šupljine i imaju klinički negativne limfne čvorove na vratu. U 30 bolesnika oboljelih od oralnog planocelularnog karcinoma (26 muškaraca i 4 žene, prosječne dobi od 59,4 godine) je napravljena punkcija limfnih čvorova uz pomoć ultrazvuka koji su viđeni i limfoscintigrafski te uz patohistološku analizu diseciranih čvorova. Sentinel limfni čvorovi su viđeni u 93% slučaja. Upotrebom limfoscintigrafije su sentinel pozitivni čvorovi verificirani u 23 pacijenta. Punkcija uz pomoć ultrazvuka je pokazala prisutnost regionalne bolesti u 10% slučajeva, dok su uz pomoć sentinel biopsije otkrivena 23 konvertirana vrata. Patohistološki nalaz je bio pozitivan u 33% bolesnika. Rezultati ovog istraživanja pokazuju kako se sentinel biopsijom nije otkrilo 27% bolesnika sa pozitivnim patohistološkim nalazom limfnih čvorova vrata. Zaključno, sentinel biopsija limfnih čvorova se treba napraviti u izdvojenim slučajevima jer je na nekim mjestima lakše napraviti disekciju vrata u odnosu na sentinel biopsiju limfnih čvorova.

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