Severe acute pancreatitis as a part of multiple dysfunction syndrome [Teški akutni pankreatitis kao dio sindroma višestrukog poremećaja funkcije organa]

Gašparović, Vladimir and Đaković, Kristina and Gornik, Ivan and Radonić, Radovan (2014) Severe acute pancreatitis as a part of multiple dysfunction syndrome [Teški akutni pankreatitis kao dio sindroma višestrukog poremećaja funkcije organa]. Collegium Antropologicum, 38 (1). pp. 125-128. ISSN 0350-6134

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Abstract

Acute pancreatitis is a disease with various degrees of clinical manifestations. Mild and moderate severe acute pancreatitis is an illness characterized with chemical inflammation which, in general, passes without major complications. Clinical picture of severe acute pancreatitis other side is commonly complicated with functional deterioration of other organs, and frequently has characteristics of multiple organ dysfunction or failure syndrome with or without bacterial super infection. We studied 82 patients admitted to the intensive care unit with severe acute pancreatitis, 14 died. The mortality was in statistically significant correlation with the severity of clinical condition at admission assessed by APACHE II score, and higher Ranson's and Glasgow criteria by admission. Adequate volume supplementation, on time, as well as percutaneous drainage of infected pancreas collection reduces a risk of pure outcome.

Abstract in Croatian

Akutni pankreatitis je stanje sa različitim kliničkim manifestacijama. Blagi i umjereno teški oblik akutnog pankreatitisa je oboljenje karakterizirano kemijskom upalom, koja u pravilu prolazi bez većih komplikacija. Klinička slika teškog pankreatitisa komplicirana je oštećenjem niza organskih sustava i često ima karakteristike višestruke disfunkcije organa ili čak zatajenja s ili bez bakterijske superinfekcije. Obradili smo 82 bolesnika s kliničkom slikom teškog akutnog pankreatitisa upućenih u Intenzivnu jedinicu, od kojih je 14 završilo letalno. Smrtnost pacijenata s teškim pankreatitisom statistički značajno korelirala je težini kliničkog stanja prema APACHE II skoru, te višim skorovima po Ranson i Glasgow kriterijima. Pravovremena volumna nadoknada i perkutane drenaže inficirane pankreasne kolekcije smanjuje rizik lošeg ishoda.

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