Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis

Erdem, Hakan and Cag, Yasemin and Ozturk-Engin, Derya and Defres, Sylviane and Kaya, Selcuk and Larsen, Lykke and Poljak, Mario and Baršić, Bruno and Argemi, Xavier and Sørensen, Signe Maj and Bohr, Anne Lisbeth and Tattevin, Pierre and Gunst, Jesper Damsgaard and Baštáková, Lenka and Jereb, Matjaž and Johansen, Isik Somuncu and Karabay, Oguz and Pekok, Abdullah Umut and Sipahi, Oguz Resat and Chehri, Mahtab and Beraud, Guillaume and Shehata, Ghaydaa and Del Vecchio, Rosa Fontana and Maresca, Mauro and Karsen, Hasan and Sengoz, Gonul and Sunbul, Mustafa and Yilmaz, Gulden and Yilmaz, Hava and Sharif-Yakan, Ahmad and Kanj, Souha Shararah and Parlak, Emine and Pehlivanoglu, Filiz and Korkmaz, Fatime and Komur, Suheyla and Kose, Sukran and Ulug, Mehmet and Bolukcu, Sibel and Coskuner, Seher Ayten and Ince, Nevin and Akkoyunlu, Yasemin and Halac, Gulistan and Sahin-Horasan, Elif and Tireli, Hulya and Kilicoglu, Gamze and Al-Mahdawi, Akram and Nemli, Salih Atakan and Inan, Asuman and Senbayrak, Seniha and Stahl, Jean Paul and Vahaboglu, Haluk (2015) Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis. Antimicrobial Agents and Chemotherapy, 59 (6). pp. 3084-9. ISSN 0066-4804

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Abstract

Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.

Item Type: Article
Additional Information: Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Departments: Katedra za infektologiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Erdem, HakanUNSPECIFIED
Cag, YaseminUNSPECIFIED
Ozturk-Engin, DeryaUNSPECIFIED
Defres, SylvianeUNSPECIFIED
Kaya, SelcukUNSPECIFIED
Larsen, LykkeUNSPECIFIED
Poljak, MarioUNSPECIFIED
Baršić, BrunoUNSPECIFIED
Argemi, XavierUNSPECIFIED
Sørensen, Signe MajUNSPECIFIED
Bohr, Anne LisbethUNSPECIFIED
Tattevin, PierreUNSPECIFIED
Gunst, Jesper DamsgaardUNSPECIFIED
Baštáková, LenkaUNSPECIFIED
Jereb, MatjažUNSPECIFIED
Johansen, Isik SomuncuUNSPECIFIED
Karabay, OguzUNSPECIFIED
Pekok, Abdullah UmutUNSPECIFIED
Sipahi, Oguz ResatUNSPECIFIED
Chehri, MahtabUNSPECIFIED
Beraud, GuillaumeUNSPECIFIED
Shehata, GhaydaaUNSPECIFIED
Del Vecchio, Rosa FontanaUNSPECIFIED
Maresca, MauroUNSPECIFIED
Karsen, HasanUNSPECIFIED
Sengoz, GonulUNSPECIFIED
Sunbul, MustafaUNSPECIFIED
Yilmaz, GuldenUNSPECIFIED
Yilmaz, HavaUNSPECIFIED
Sharif-Yakan, AhmadUNSPECIFIED
Kanj, Souha ShararahUNSPECIFIED
Parlak, EmineUNSPECIFIED
Pehlivanoglu, FilizUNSPECIFIED
Korkmaz, FatimeUNSPECIFIED
Komur, SuheylaUNSPECIFIED
Kose, SukranUNSPECIFIED
Ulug, MehmetUNSPECIFIED
Bolukcu, SibelUNSPECIFIED
Coskuner, Seher AytenUNSPECIFIED
Ince, NevinUNSPECIFIED
Akkoyunlu, YaseminUNSPECIFIED
Halac, GulistanUNSPECIFIED
Sahin-Horasan, ElifUNSPECIFIED
Tireli, HulyaUNSPECIFIED
Kilicoglu, GamzeUNSPECIFIED
Al-Mahdawi, AkramUNSPECIFIED
Nemli, Salih AtakanUNSPECIFIED
Inan, AsumanUNSPECIFIED
Senbayrak, SenihaUNSPECIFIED
Stahl, Jean PaulUNSPECIFIED
Vahaboglu, HalukUNSPECIFIED
Date: 2015
Date Deposited: 28 Jan 2016 11:46
Last Modified: 28 Jan 2016 11:46
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2385

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