Polycystic ovary syndrome: important underrecognised cardiometabolic risk factor in reproductive-age women

Pavičić Baldani, Dinka and Škrgatić, Lana and Ougouag, Roya (2015) Polycystic ovary syndrome: important underrecognised cardiometabolic risk factor in reproductive-age women. International Journal of Endocrinology, 2015. p. 786362. ISSN 1687-8337

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Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age. Although PCOS is diagnosed exclusively based on reproductive criteria, it is also a metabolic disorder. Insulin resistance, impaired glucose tolerance, type 2 diabetes mellitus, obesity, and dyslipidemia are more common in women with PCOS than in age-comparable women without PCOS. Many of the metabolic abnormalities that manifest in PCOS are worsened by the concurrent incidence of obesity. However, some of these metabolic perturbations occur even in lean women with PCOS and therefore are rightfully recognized as intrinsic to PCOS. The intrinsic factors that produce these metabolic disturbances are reviewed in this paper. The consequences of obesity and the other metabolic aberrations are also discussed. The metabolic perturbations in PCOS patients lead to chronic low-grade inflammation and to cardiovascular impairments that heighten the risk of having cardiovascular disease. Even though many studies have shown an elevation in surrogate biomarkers of cardiovascular disease in PCOS women, it is still not clear to what extent and magnitude the elevation precipitates more frequent and earlier events.

Item Type: Article
Additional Information: Copyright © 2015 Dinka Pavičić Baldani et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Departments: Katedra za ginekologiju i opstetriciju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Pavičić Baldani, DinkaUNSPECIFIED
Škrgatić, LanaUNSPECIFIED
Ougouag, RoyaUNSPECIFIED
Date: 2015
Date Deposited: 13 Jan 2016 10:53
Last Modified: 23 Jul 2020 08:47
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2370

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