The influence of body position on cerebrospinal fluid pressure gradient and movement in cats with normal and impaired craniospinal communication

Klarica, Marijan and Radoš, Milan and Erceg, Gorislav and Petošić, Antonio and Jurjević, Ivana and Orešković, Darko (2014) The influence of body position on cerebrospinal fluid pressure gradient and movement in cats with normal and impaired craniospinal communication. PLoS ONE, 9 (4). e95229. ISSN 1932-6203

PDF - Published Version
Download (2MB) | Preview


Intracranial hypertension is a severe therapeutic problem, as there is insufficient knowledge about the physiology of cerebrospinal fluid (CSF) pressure. In this paper a new CSF pressure regulation hypothesis is proposed. According to this hypothesis, the CSF pressure depends on the laws of fluid mechanics and on the anatomical characteristics inside the cranial and spinal space, and not, as is today generally believed, on CSF secretion, circulation and absorption. The volume and pressure changes in the newly developed CSF model, which by its anatomical dimensions and basic biophysical features imitates the craniospinal system in cats, are compared to those obtained on cats with and without the blockade of craniospinal communication in different body positions. During verticalization, a long-lasting occurrence of negative CSF pressure inside the cranium in animals with normal cranio-spinal communication was observed. CSF pressure gradients change depending on the body position, but those gradients do not enable unidirectional CSF circulation from the hypothetical site of secretion to the site of absorption in any of them. Thus, our results indicate the existence of new physiological/pathophysiological correlations between intracranial fluids, which opens up the possibility of new therapeutic approaches to intracranial hypertension.

Item Type: Article
Additional Information: Copyright: © 2014 Klarica et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
MeSH: Animals ; Cats ; Cerebrospinal Fluid Pressure ; Movement ; Posture ; Spine/physiopathology
Departments: Hrvatski institut za istraživanje mozga
Katedra za farmakologiju
Depositing User: Marijan Šember
Status: Published
Klarica, MarijanUNSPECIFIED
Erceg, GorislavUNSPECIFIED
Petošić, AntonioUNSPECIFIED
Jurjević, IvanaUNSPECIFIED
Orešković, DarkoUNSPECIFIED
Date: 18 April 2014
Date Deposited: 21 Dec 2015 10:34
Last Modified: 17 Jul 2020 08:20
Subjects: /
Related URLs:

Actions (login required)

View Item View Item


Downloads per month over past year