Developmental dynamics of radial vulnerability in the cerebral compartments in preterm infants and neonates

Kostović, Ivica and Kostović-Srzentić, Mirna and Benjak, Vesna and Jovanov-Milošević, Nataša and Radoš, Milan (2014) Developmental dynamics of radial vulnerability in the cerebral compartments in preterm infants and neonates. Frontiers in Neurology, 5. p. 139. ISSN 1664-2295

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The developmental vulnerability of different classes of axonal pathways in preterm white matter is not known. We propose that laminar compartments of the developing cerebral wall serve as spatial framework for axonal growth and evaluate potential of anatomical landmarks for understanding reorganization of the cerebral wall after perinatal lesions. The 3-T MRI (in vivo) and histological analysis were performed in a series of cases ranging from 22 postconceptional weeks to 3 years. For the follow-up scans, three groups of children (control, normotypic, and preterms with lesions) were examined at the term equivalent age and after the first year of life. MRI and histological abnormalities were analyzed in the following compartments: (a) periventricular, with periventricular fiber system; (b) intermediate, with periventricular crossroads, sagittal strata, and centrum semiovale; (c) superficial, composed of gyral white matter, subplate, and cortical plate. Vulnerability of thalamocortical pathways within the crossroads and sagittal strata seems to be characteristic for early preterms, while vulnerability of long association pathways in the centrum semiovale seems to be predominant feature of late preterms. The structural indicator of the lesion of the long association pathways is the loss of delineation between centrum semiovale and subplate remnant, which is possible substrate of the diffuse periventricular leukomalacia. The enhanced difference in MR signal intensity of centrum semiovale and subplate remnant, observed in damaged children after first year, we interpret as structural plasticity of intact short cortico-cortical fibers, which grow postnatally through U-zones and enter the cortex through the subplate remnant. Our findings indicate that radial distribution of MRI signal abnormalities in the cerebral compartments may be related to lesion of different classes of axonal pathways and have prognostic value for predicting the likely outcome of prenatal and perinatal lesions.

Item Type: Article
Additional Information: Copyright: © 2014 Kostović, Kostović-Srzentić, Benjak, Jovanov-Milošević and Radoš. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Departments: Hrvatski institut za istraživanje mozga
Depositing User: Marijan Šember
Status: Published
Kostović, IvicaUNSPECIFIED
Kostović-Srzentić, MirnaUNSPECIFIED
Jovanov-Milošević, NatašaUNSPECIFIED
Date: 29 July 2014
Date Deposited: 21 Dec 2015 09:11
Last Modified: 17 Jul 2020 08:26
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