Baseline level of platelet-leukocyte aggregates, platelet CD63 expression, and soluble P-selectin concentration in patients with posttraumatic stress disorder: A pilot study

Vidović, Anđelko and Vilibić, Maja and Markotić, Alemka and Sabioncello, Ante and Gotovac, Katja and Folnegović-Šmalc, Vera and Dekaris, Dragan (2007) Baseline level of platelet-leukocyte aggregates, platelet CD63 expression, and soluble P-selectin concentration in patients with posttraumatic stress disorder: A pilot study. Psychiatry Research, 150 (2). pp. 211-216. ISSN 0165-1781

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Abstract

Platelets may have an important role in the development of cardiovascular disease (CVD) as a result of chronic stress. We conducted a pilot study to evaluate the effect of posttraumatic stress disorder (PTSD) on baseline platelet activation. Platelet-leukocyte aggregates (PLA) and CD63 expression were measured by flow cytometry, and soluble (s)P-selectin concentration was determined in sera of 20 Croatian male combat veterans with PTSD and 20 healthy civilians. Groups were matched in sex, age, body mass index (BMI) and traditional CVD risk factors. Our data showed no differences in measured parameters. Other platelet activation markers should be determined and a larger sample size used in future studies.

Item Type: Article
MeSH: Antigens, CD - blood ; Blood Platelets - metabolism ; Combat Disorders - blood - diagnosis - psychology ; Leukocytes - metabolism ; P-Selectin - blood ; Platelet Aggregation - physiology ; Veterans - psychology ; Adult ; Body Mass Index ; Cardiovascular Diseases - blood ; Croatia ; Flow Cytometry ; Humans ; Male ; Middle Aged ; Pilot Projects ; Platelet Membrane Glycoproteins ; Risk Factors
Departments: Katedra za psihijatriju i psihološku medicinu
Depositing User: Lea Škorić
Status: Published
Creators:
CreatorsEmail
Vidović, AnđelkoUNSPECIFIED
Vilibić, MajaUNSPECIFIED
Markotić, AlemkaUNSPECIFIED
Sabioncello, AnteUNSPECIFIED
Gotovac, KatjaUNSPECIFIED
Folnegović-Šmalc, VeraUNSPECIFIED
Dekaris, Dragan UNSPECIFIED
Date: March 2007
Date Deposited: 12 Oct 2007
Last Modified: 23 Sep 2011 16:10
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/236

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