American ginseng extract (Panax quinquefolius L.) is safe in long-term use in type 2 diabetic patients.

Mucalo, Iva and Jovanovski, Elena and Vuksan, Vladimir and Božikov, Velimir and Romić, Željko and Rahelić, Dario (2014) American ginseng extract (Panax quinquefolius L.) is safe in long-term use in type 2 diabetic patients. Evidence-Based Complementary and Alternative Medicine, 2014. p. 969168. ISSN 1741-427X

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Abstract

Aim. The objective of the present study was to test the safety of supplementation with the American ginseng (AG) interventional material as an adjunct to conventional therapy (diet and/or medications) in type 2 diabetes, using a double-blind, randomized, placebo-controlled, parallel design. ----- Methods. Each participant received either AG (10% ginsenosides) or placebo capsules (500 mg/meal = 3 g/day) for a period of 12 weeks. Outcomes included measures of safety including kidney function (urates and creatinine), liver function (AST and ALT), and haemostatic function (PV and INR). ----- Results. Seventy-four participants with well-controlled type 2 diabetes (sex: 28 M and 46 F, age: 63 ± 9.5, BMI: 32 ± 5, and HbA1c: 7 ± 1.3), randomized to either intervention (n = 35) or control (n = 39) group, completed the study. There was no change in any of the measures of safety between treatments from baseline. The number or severity of adverse events did not differ between the AG intervention and placebo. ----- Conclusion. Following 12 weeks of supplementation with AG, safety was not compromised in a high cardiovascular disease (CVD) risk population of patients with type 2 diabetes. This demonstrated that safety is noteworthy, as reviews have continuously warned of possible adverse effects of ginseng consumption.

Item Type: Article
Additional Information: Copyright © 2014 Iva Mucalo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Departments: Katedra za internu medicinu
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Mucalo, IvaUNSPECIFIED
Jovanovski, ElenaUNSPECIFIED
Vuksan, VladimirUNSPECIFIED
Božikov, VelimirUNSPECIFIED
Romić, ŽeljkoUNSPECIFIED
Rahelić, DarioUNSPECIFIED
Date: 2014
Date Deposited: 16 Dec 2015 13:50
Last Modified: 16 Dec 2015 13:51
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2356

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