Endoscopic ultrasound guided fine needle aspiration and useful ancillary methods

Tadić, Mario and Štoos-Veić, Tajana and Kušec, Rajko (2014) Endoscopic ultrasound guided fine needle aspiration and useful ancillary methods. World Journal of Gastroenterology, 20 (39). pp. 14292-14300. ISSN 1007-9327

PDF - Published Version
Download (944kB) | Preview


The role of endoscopic ultrasound (EUS) in evaluating pancreatic pathology has been well documented from the beginning of its clinical use. High spatial resolution and the close proximity to the evaluated organs within the mediastinum and abdominal cavity allow detection of small focal lesions and precise tissue acquisition from suspected lesions within the reach of this method. Fine needle aspiration (FNA) is considered of additional value to EUS and is performed to obtain tissue diagnosis. Tissue acquisition from suspected lesions for cytological or histological analysis allows, not only the differentiation between malignant and non-malignant lesions, but, in most cases, also the accurate distinction between the various types of malignant lesions. It is well documented that the best results are achieved only if an adequate sample is obtained for further analysis, if the material is processed in an appropriate way, and if adequate ancillary methods are performed. This is a multi-step process and could be quite a challenge in some cases. In this article, we discuss the technical aspects of tissue acquisition by EUS-guided-FNA (EUS-FNA), as well as the role of an on-site cytopathologist, various means of specimen processing, and the selection of the appropriate ancillary method for providing an accurate tissue diagnosis and maximizing the yield of this method. The main goal of this review is to alert endosonographers, not only to the different possibilities of tissue acquisition, namely EUS-FNA, but also to bring to their attention the importance of proper sample processing in the evaluation of various lesions in the gastrointestinal tract and other accessible organs. All aspects of tissue acquisition (needles, suction, use of stylet, complications, etc.) have been well discussed lately. Adequate tissue samples enable comprehensive diagnoses, which answer the main clinical questions, thus enabling targeted therapy.

Item Type: Article
Additional Information: Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
MeSH: Biological Markers/analysis ; Cytogenetic Analysis ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/adverse effects ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/instrumentation ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods ; Flow Cytometry ; Humans ; Immunohistochemistry ; Immunophenotyping ; Molecular Diagnostic Techniques ; Predictive Value of Tests ; Reproducibility of Results
Departments: Katedra za internu medicinu
Depositing User: Marijan Šember
Status: Published
Štoos-Veić, TajanaUNSPECIFIED
Date: 21 October 2014
Date Deposited: 09 Dec 2015 13:32
Last Modified: 20 Jul 2020 07:57
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2348

Actions (login required)

View Item View Item


Downloads per month over past year