Lower incidence of hepatic metastases of colorectal cancer in patients with chronic liver diseases: meta-analysis

Augustin, Goran and Bruketa, Tomislav and Korolija, Dragan and Milošević, Milan (2013) Lower incidence of hepatic metastases of colorectal cancer in patients with chronic liver diseases: meta-analysis. Hepato-Gastroenterology, 60 (125). pp. 1164-1168. ISSN 0172-6390

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Abstract

BACKGROUND/AIMS The rarity of metastatic malignancy in injured liver has been noticed. This meta-analysis evaluates the difference in occurrence of metastatic colorectal cancer in healthy and chronically injured liver. ----- METHODOLOGY Literature search of occurrence of metastatic colorectal cancer in chronically injured liver opposed to healthy liver was conducted. Chronically injured/damaged liver included cirrhosis, steatosis or fatty liver and infection with Hepatitis virus B or C. ----- RESULTS A total of 7 retrospective studies between 1992 and 2010 matched the selection criteria with total of 4049 patients. Results suggest significantly lower incidence of colorectal metastasis in chronically injured liver (Pooled odds ratio = 0.260 (95% CI = 0.18 to 0.38); χ² (test odds ratio differs from 1) = 45.90 (df = 1); p <0.0001). ----- CONCLUSIONS Patients with chronic liver injury have significantly lower occurrence of hepatic metastasis of primary colorectal cancer than the patients with healthy liver.

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