Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Histopathologic parameters as predictors of response to endoscopic sinus surgery in nonallergic patients with chronic rhinosinusitis

Baudoin, Tomislav and Čupić, Hrvoje and Geber, Goran and Vagić, Davor and Grgić, Marko and Kalogjera, Livije (2006) Histopathologic parameters as predictors of response to endoscopic sinus surgery in nonallergic patients with chronic rhinosinusitis. Otolaryngology - head and neck surgery, 134 (5). pp. 761-766. ISSN 0194-5998

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    English abstract

    OBJECTIVE: To estimate the predictable value of histopathologic parameters in chronic rhinosinusitis (CRS) for response to endoscopic sinus surgery (ESS). - - - - - STUDY DESIGN: Symptomatology was rated in 100 patients prior to as well as 12 and 24 months after surgery. Specimens taken during the procedure were examined and scored for goblet cells, subepithelial thickening, mast cells, and eosinophils. Multiple regression analysis was performed to predict the total score of subjective symptoms before treatment by histopathologic parameters. The correlation between histopathologic parameters and postoperative symptoms was then evaluated. - - - - - RESULTS: Goblet cells were the best predictor correlating with 5 symptoms. Subepithelial thickening correlated with 4 symptoms. Mast cell infiltration correlated with 3 symptoms. Eosinophilic infiltration correlated with only one symptom (P<0.05). - - - - - CONCLUSION: Certain histopathologic parameters in CRS are predictive of favorable response to ESS. - - - - - SIGNIFICANCE: Pathologic evaluation may help the ENT surgeon to predict the persistence of certain CRS symptoms after ESS, even in patients at low risk for surgical failure. - - - - - EBM rating: C-4.

    Item Type: Article
    MeSH: Endoscopy ; Nasal Mucosa - pathology ; Otorhinolaryngologic Surgical Procedures - methods ; Rhinitis - complications - pathology - surgery ; Sinusitis - complications - pathology - surgery ; Adult ; Biopsy ; Cell Count ; Eosinophils - pathology ; Female ; Goblet Cells - pathology ; Humans ; Male ; Mast Cells - pathology ; Prognosis ; Retrospective Studies ; Severity of Illness Index
    Divisions: Katedra za otorinoloringologiju s audiologijom i fonijatrijom
    Depositing User: Lea Škorić
    Status: Published
    Creators:
    CreatorsEmail
    Baudoin, Tomislav
    Čupić, Hrvoje
    Geber, Goran
    Vagić, Davor
    Grgić, Marko
    Kalogjera, Livije
    Date: May 2006
    Date Deposited: 06 Mar 2007
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/233

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