Familial antiphospholipid syndrome presenting as bivessel arterial occlusion in a 17-year-old girl

Jelušić, Marija and Starčević, Katarina and Vidović, Mandica and Dobrota, Savko and Potočki, Kristina and Banfić, Ljiljana and Anić, Branimir (2013) Familial antiphospholipid syndrome presenting as bivessel arterial occlusion in a 17-year-old girl. Rheumatology International, 33 (5). pp. 1359-1362. ISSN 0172-8172

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This article presents a case of a 17-year-old girl with primary antiphospholipid syndrome developing subacute signs of hand and leg ischaemia caused by radiologically verified radial and popliteal artery occlusion. She is successfully treated with a thrombolytic agent (alteplase) and recovers completely. Her laboratory results came positive for all three subtypes of antiphospholipid antibodies. This kind of antiphospholipid syndrome presentation is a very rare entity in itself. Shortly afterwards her mother is diagnosed with primary antiphospholipid syndrome as well. A familial form of antiphospholipid syndrome is suspected. Combination of a familial antiphospholipid syndrome presenting as bivessel arterial thrombosis is a unique case, to the best of our knowledge, never described in the literature before.

Item Type: Article
MeSH: Administration, Oral ; Adolescent ; Angiography, Digital Subtraction ; Antibodies, Antiphospholipid/blood ; Anticoagulants/administration & dosage ; Antiphospholipid Syndrome/blood ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/genetics ; Antiphospholipid Syndrome/immunology ; Arterial Occlusive Diseases/blood ; Arterial Occlusive Diseases/diagnosis ; Arterial Occlusive Diseases/drug therapy ; Arterial Occlusive Diseases/etiology ; Biological Markers/blood ; Constriction, Pathologic ; Female ; Fibrinolytic Agents/therapeutic use ; Genetic Predisposition to Disease ; Heredity ; Humans ; Ischemia/etiology ; Pedigree ; Popliteal Artery/radiography ; Radial Artery/radiography ; Thrombolytic Therapy ; Tissue Plasminogen Activator/therapeutic use ; Treatment Outcome ; Warfarin/administration & dosage
Departments: Katedra za internu medicinu
Katedra za radiologiju i opću kliničku onkologiju
Depositing User: Marijan Šember
Status: Published
Jelušić, MarijaUNSPECIFIED
Starčević, KatarinaUNSPECIFIED
Vidović, MandicaUNSPECIFIED
Potočki, KristinaUNSPECIFIED
Banfić, LjiljanaUNSPECIFIED
Date: May 2013
Date Deposited: 26 Oct 2015 09:31
Last Modified: 13 Jul 2020 09:21
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2327

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