Jelušić, Marija and Starčević, Katarina and Vidović, Mandica and Dobrota, Savko and Potočki, Kristina and Banfić, Ljiljana and Anić, Branimir (2013) Familial antiphospholipid syndrome presenting as bivessel arterial occlusion in a 17-year-old girl. Rheumatology International, 33 (5). pp. 1359-1362. ISSN 0172-8172
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Abstract
This article presents a case of a 17-year-old girl with primary antiphospholipid syndrome developing subacute signs of hand and leg ischaemia caused by radiologically verified radial and popliteal artery occlusion. She is successfully treated with a thrombolytic agent (alteplase) and recovers completely. Her laboratory results came positive for all three subtypes of antiphospholipid antibodies. This kind of antiphospholipid syndrome presentation is a very rare entity in itself. Shortly afterwards her mother is diagnosed with primary antiphospholipid syndrome as well. A familial form of antiphospholipid syndrome is suspected. Combination of a familial antiphospholipid syndrome presenting as bivessel arterial thrombosis is a unique case, to the best of our knowledge, never described in the literature before.
| Item Type: | Article | ||||||||||||||||
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| MeSH: | Administration, Oral ; Adolescent ; Angiography, Digital Subtraction ; Antibodies, Antiphospholipid/blood ; Anticoagulants/administration & dosage ; Antiphospholipid Syndrome/blood ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/genetics ; Antiphospholipid Syndrome/immunology ; Arterial Occlusive Diseases/blood ; Arterial Occlusive Diseases/diagnosis ; Arterial Occlusive Diseases/drug therapy ; Arterial Occlusive Diseases/etiology ; Biological Markers/blood ; Constriction, Pathologic ; Female ; Fibrinolytic Agents/therapeutic use ; Genetic Predisposition to Disease ; Heredity ; Humans ; Ischemia/etiology ; Pedigree ; Popliteal Artery/radiography ; Radial Artery/radiography ; Thrombolytic Therapy ; Tissue Plasminogen Activator/therapeutic use ; Treatment Outcome ; Warfarin/administration & dosage | ||||||||||||||||
| Departments: | Katedra za internu medicinu Katedra za radiologiju i opću kliničku onkologiju |
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| Depositing User: | Marijan Šember | ||||||||||||||||
| Status: | Published | ||||||||||||||||
| Creators: |
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| Date: | May 2013 | ||||||||||||||||
| Date Deposited: | 26 Oct 2015 09:31 | ||||||||||||||||
| Last Modified: | 13 Jul 2020 09:21 | ||||||||||||||||
| Subjects: | / | ||||||||||||||||
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| URI: | http://medlib.mef.hr/id/eprint/2327 |
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