Bedenić, Branka and Sardelić, Sanda and Vranić-Ladavac, Mirna and Barišić, Nada and Ladavac, Ranko (2014) Karbapenemaze gram-negativnih bakterija [Carbapenemases of gram-negative bacteria]. Liječnički vjesnik, 136 (3-4). pp. 94-103. ISSN 0024-3477
![[img]](http://medlib.mef.hr/style/images/fileicons/application_pdf.png)
|
PDF
- Published Version
Download (408kB) | Preview |
Abstract
Carbapenems are often antibiotics of last resort for the treatment of severe infections. They are stable to most beta-lactamases produced by gram-negative bacteria. However, bacterial enzymes named carbapenemases can efficiently hydrolyze carbapenems. They are produced most frequently by Enterobacteriaceae and non-fermentative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannnii. They belong to group A (KPC, SME, IMI, NMC), B (VIM, IMP, SPM, GIM, NDM, SIM, DIM, AIM) and D (OXA-23, OXA-24, OXA-48, OXA-58, OXA-143). The accurate and rapid laboratory identification of carbapenem-resistant isolates is important to prevent spread of such multidrug resistant strains and to avoid therapeutic failures. Therapeutic options are often limited because carbapenemases are encoded on mobile genetic elements which often harbour resistance genes to other groups of antibiotics. Thus, colistin is often the only therapeutic option.
Abstract in Croatian
Karbapenemi su često jedina terapijska opcija za liječenje teških infekcija. Stabilni su prema većini b-laktamaza gram-negativnih bakterija, ali neke b-laktamaze, koje se zovu karbapenemaze, mogu ih djelotvorno hidrolizirati. Nalazimo ih u izolatima enterobakterija i nefermentativnih bakterija kao što su Pseudomonas aeruginosa i Acinetobacter baumannii. Dijele se u klase A (KPC, SME, IMI, NMC), B (VIM, IMP, SPM, GIM, NDM, SIM, DIM, AIM) i D (OXA-23, OXA-24, OXA-48, OXA-58, OXA-143). Pravilna i brza identifikacija karbapenem-rezistentnih izolata u laboratoriju važna je kako bi se spriječilo širenje takvih sojeva unutar bolnica i kako bi se izbjegao terapijski neuspjeh. Terapijske opcije vrlo su ograničene zbog toga što prenosivi genski elementi koji kodiraju te b-laktamaze obično sadržavaju i gene rezistencije na ostale antibiotike i često ostaje kolistin kao jedini lijek izbora.
| Item Type: | Article | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MeSH: | Bacterial Proteins / drug effects ; Bacterial Proteins / metabolism ; Carbapenems / therapeutic use ; Drug Resistance, Microbial / drug effects ; Enterobacter cloacae / enzymology ; Enterobacteriaceae / enzymology ; Gram-Negative Bacterial Infections / drug therapy ; Gram-Negative Bacterial Infections / microbiology ; Humans ; Klebsiella pneumoniae / enzymology ; Pseudomonas aeruginosa / enzymology ; beta-Lactamases / drug effects ; beta-Lactamases / metabolism | ||||||||||||
| Departments: | Katedra za medicinsku mikrobiologiju i parazitologiju | ||||||||||||
| Depositing User: | Marijan Šember | ||||||||||||
| Status: | Published | ||||||||||||
| Creators: |
|
||||||||||||
| Date: | March 2014 | ||||||||||||
| Date Deposited: | 15 Oct 2015 12:33 | ||||||||||||
| Last Modified: | 16 Jul 2020 09:03 | ||||||||||||
| Subjects: | / | ||||||||||||
| Related URLs: | |||||||||||||
| URI: | http://medlib.mef.hr/id/eprint/2316 |
Actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
