Intraoral adenoid cystic carcinoma: is the presence of perineural invasion associated with the size of the primary tumour, local extension, surgical margins, distant metastases, and outcome?

Lukšić, Ivica and Suton, Petar and Macan, Darko and Dinjar, Kristijan (2014) Intraoral adenoid cystic carcinoma: is the presence of perineural invasion associated with the size of the primary tumour, local extension, surgical margins, distant metastases, and outcome? British Journal of Oral & Maxillofacial Surgery, 52 (3). pp. 214-8. ISSN 0266-4356

[img]
Preview
PDF
Download (407kB) | Preview

Abstract

Adenoid cystic carcinoma is the most common malignancy of the minor salivary glands, and its biological behaviour is characterised by slow and indolent growth; rare involvement of regional lymph nodes; a high propensity for perineural invasion; multiple or delayed recurrences, or both; and a high incidence of distant metastases. Our aim was to find out the relation between the presence of perineural invasion and these factors. Between 1 January 1984 and 1 May 2008, 26 cases of adenoid cystic carcinoma of the intraoral salivary glands, which had initially been treated surgically, were reviewed retrospectively. The most common site was the palate, and perineural invasion was reported in 13 of the 26 resected specimens. There was no significant association between it and the size of the primary tumour (OR=1.0; p=1.00), invasion of the surgical margins (OR=2.08; p=0.4), the presence of distant metastases (OR=3.43; p=0.197), or local control (p=0.76). It was exclusively present in patients with local extension, and was significantly associated with outcome (p=0.04). Resection with clear margins is the gold standard of care for patients with intraoral adenoid cystic carcinoma, and the role of adjuvant irradiation remains controversial. Given its paradoxical and complex biological behaviour, large studies with long term follow-up are needed to define the clinicopathological and immunohistochemical variables associated with outcome, as well as the optimal treatment.

Item Type: Article
MeSH: Adult ; Aged ; Aged, 80 and over ; Carcinoma, Adenoid Cystic/pathology ; Carcinoma, Adenoid Cystic/secondary ; Cause of Death ; Female ; Follow-Up Studies ; Humans ; Lymphatic Metastasis/pathology ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Nerve Fibers/pathology ; Palatal Neoplasms/pathology ; Radiotherapy, Adjuvant ; Retrospective Studies ; Salivary Gland Neoplasms/pathology ; Survival Rate ; Treatment Outcome
Departments: Katedra za maksilofacijalnu kirurgiju sa stomatologijom
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Lukšić, IvicaUNSPECIFIED
Suton, PetarUNSPECIFIED
Macan, DarkoUNSPECIFIED
Dinjar, KristijanUNSPECIFIED
Date: March 2014
Date Deposited: 23 Sep 2015 10:06
Last Modified: 23 Sep 2015 10:06
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2275

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year