Association of antinociceptive action of botulinum toxin type A with GABA-A receptor

Drinovac, Višnja and Bach-Rojecky, Lidija and Lacković, Zdravko (2014) Association of antinociceptive action of botulinum toxin type A with GABA-A receptor. Journal of Neural Transmission, 121 (6). pp. 665-669. ISSN 0300-9564

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Official URL: https://doi.org/10.1007/s00702-013-1150-6

Abstract

The mechanism of botulinum toxin type A (BTX-A) antinociceptive action in the central nervous system is little known. The potential interaction between BTX-A and GABAergic system has not been investigated previously. In the present study, we demonstrate prevention of BTX-A antinociceptive effect on formalin-induced inflammatory pain and partial sciatic nerve transection-induced mechanical allodynia by GABA-A antagonist bicuculline, thus suggesting association of the GABA-A receptors and antinociceptive action of BTX-A.

Item Type:

Article

MeSH:

Animals ; Bicuculline/pharmacology ; Botulinum Toxins, Type A/therapeutic use ; Disease Models, Animal ; Drug Administration Routes ; Formaldehyde/toxicity ; Hyperalgesia/drug therapy ; Neurotoxins/therapeutic use ; Pain/chemically induced ; Pain/prevention & control ; Pain Measurement/drug effects ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Rats, Wistar ; Receptors, GABA-A/metabolism ; Sciatica/prevention & control

Departments:

Katedra za farmakologiju

Depositing User:

Marijan Šember

Status:

Published

Creators: