Possible target for preventing fibrotic scar formation following acute myocardial infarction

Cvjetičanin, Bruno and Prutki, Maja and Dumić-Čule, Ivo and Veir, Zoran and Grgurević, Lovorka and Vukičević, Slobodan (2014) Possible target for preventing fibrotic scar formation following acute myocardial infarction. Medical Hypotheses, 83 (6). pp. 656-658. ISSN 0306-9877

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Bone morphogenetic protein 1 (BMP1) was originally isolated from bone with other BMPs due to its affinity for heparin. While all other BMPs are members of the Transforming Growth Factor β (TGFβ) superfamily of growth factors, BMP1 is not an authentic member of the BMP protein family. Together with mammalian Tolloid Like protein 1 (mTLL-1) and mTLL-2, BMP1 comprise a small group of zinc- and calcium-dependent proteinases. Acute myocardial infarction (AMI) is the leading cause of death in developed countries which accounts for 13% of deaths worldwide. It was recently shown that inhibition of BMP1-3 reduces progression of fibrosis in chronic kidney disease and suggested that BMP1-3 is an important molecule for fibrogenesis. We hypothesize that inhibition of BMP1-3 represents future of therapeutic interventions in the heart tissue fibrosis following AMI. This novel approach aims to acquire the first candidate specific treatment for recuperating the heart function in patients with AMI.

Item Type: Article
MeSH: Antibodies, Monoclonal / chemistry ; Bone Morphogenetic Protein 1 / metabolism ; Cicatrix / prevention & control ; Disease Progression ; Fibrosis / physiopathology ; Fibrosis / prevention & control ; Humans ; Models, Theoretical ; Myocardial Infarction / physiopathology ; Myocardium / pathology ; Renal Insufficiency, Chronic / physiopathology ; Tolloid-Like Metalloproteinases / metabolism ; Transforming Growth Factor beta / metabolism
Departments: Katedra za anatomiju i kliničku anatomiju
Katedra za radiologiju i opću kliničku onkologiju
Depositing User: Marijan Šember
Status: Published
Cvjetičanin, BrunoUNSPECIFIED
Grgurević, LovorkaUNSPECIFIED
Vukičević, SlobodanUNSPECIFIED
Date: December 2014
Date Deposited: 15 Sep 2015 14:09
Last Modified: 16 Jul 2020 09:33
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2258

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