Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma

Nikuševa-Martić, Tamara and Šerman, Ljiljana and Zeljko, Martina and Vidas, Željko and Gašparov, Slavko and Zeljko, Hrvojka Marija and Kosović, Marin and Pećina-Šlaus, Nives (2013) Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma. Pathology Oncology Research, 19 (3). pp. 545-551. ISSN 1219-4956

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Frequency and mortality of renal cell carcinoma (RCC) are increasing for decades. However, the molecular background of RCC tumorigenesis is still poorly understood. In current study we investigated the expression of TCF/LEF and SFRP family members (SFRP1 and SFRP3) to gain a better understanding of biological signaling pathways responsible for epidemiology and clinical parameters of clear cell RCC (cRCC). Thirty-six pairs of paraffin-embedded clear cRCC and adjacent nontumoral tissues samples using immunohistochemistry (IHC) were analyzed and compared with corresponding clinicopathological parameters. Immunohistochemistry indicated statistically significant decreased SFRP3 expression in tumor tissues but no consistency in SFRP1 expression in analyzed normal and tumor tissue. The TCF1 expression level was significantly weaker in normal tissue compared to tumor samples while LEF1 protein levels were significantly weaker in tumor tissue. To our knowledge, this is the first report on analysis of the expression of transcription factors TCF1 and LEF1 in clear cell renal cell carcinoma and their comparison with Wnt signal pathway antagonists belonging to SFRP family.

Item Type: Article
MeSH: Adult ; Aged ; Analysis of Variance ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Female ; Glycoproteins/metabolism ; Humans ; Immunohistochemistry ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Lymphoid Enhancer-Binding Factor 1/metabolism ; Male ; Middle Aged ; Principal Component Analysis ; Statistics, Nonparametric ; T Cell Transcription Factor 1/metabolism
Departments: Hrvatski institut za istraživanje mozga
Katedra za medicinsku biologiju
Depositing User: Marijan Šember
Status: Published
Nikuševa-Martić, TamaraUNSPECIFIED
Šerman, LjiljanaUNSPECIFIED
Zeljko, MartinaUNSPECIFIED
Gašparov, SlavkoUNSPECIFIED
Zeljko, Hrvojka MarijaUNSPECIFIED
Pećina-Šlaus, NivesUNSPECIFIED
Date: July 2013
Date Deposited: 14 Sep 2015 09:35
Last Modified: 14 Jul 2020 09:21
Subjects: /
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