Prevalence of Pneumocystis jirovecii pneumonia (2010-2013): the first Croatian report

Babić-Erceg, Andrea and Vilibić-Čavlek, Tatjana and Erceg, Marijan and Mlinarić-Missoni, Emilija and Begovac, Josip (2014) Prevalence of Pneumocystis jirovecii pneumonia (2010-2013): the first Croatian report. Acta Microbiologica et Immunologica Hungarica, 61 (2). pp. 181-8. ISSN 1217-8950

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Abstract

Pneumocystis jirovecii is an important cause of interstitial pneumonia particularly among immunocompromised hosts. We analysed the prevalence of P. jirovecii pneumonia (PCP) among HIV-infected and HIV-uninfected patients presented with interstitial pneumonia or acute respiratory syndrome hospitalized in six Croatian tertiary care hospitals. Over four-year period (2010-2013), a total of 328 lower respiratory tract samples: 253 (77.1%) bronchoalveolar lavage fluid, 43 (13.1%) tracheal aspirates and 32 (9.8%) bronchial aspirates from 290 patients were examined by real-time polymerase chain reaction (PCR). PCP was detected in 23 (7.9%) patients. The prevalence of PCP differed significantly among tested groups (χ2 = 95.03; d.f. = 3; p < 0.001). HIV-infected patients were more often positive (56.6%, 95%CI = 37.3-72.4) compared to other groups (patients with malignant disease 7.7%, 95%CI = 2.6-20.3; transplant patients 7.7%, 95%CI = 2.2-24.1; patients with other diagnosis 1.5%, 95%CI = 0.5-4.4). Majority of HIV-positive patients (80%) were newly diagnosed cases. Our results indicate that HIV-infected patients still represents the main risk group for P. jirovecii infection. PCP is responsible for pneumonia in 56.6% HIV-positive patients in Croatia, primarily those who do not know that they are HIV infected.

Item Type: Article
MeSH: Adult ; Aged ; Bronchoalveolar Lavage Fluid/microbiology ; Bronchoalveolar Lavage Fluid/virology ; Child, Preschool ; Comorbidity ; Croatia/epidemiology ; Female ; HIV Infections/epidemiology ; HIV Infections/immunology ; HIV Infections/microbiology ; HIV Infections/virology ; Humans ; Immunocompromised Host ; Infant ; Male ; Middle Aged ; Pneumocystis jirovecii/immunology ; Pneumocystis jirovecii/isolation & purification ; Pneumonia, Pneumocystis/epidemiology ; Pneumonia, Pneumocystis/immunology ; Pneumonia, Pneumocystis/microbiology ; Pneumonia, Pneumocystis/virology ; Prevalence ; Real-Time Polymerase Chain Reaction ; Retrospective Studies ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/immunology ; Severe Acute Respiratory Syndrome/microbiology ; Severe Acute Respiratory Syndrome/virology
Departments: Katedra za infektologiju
Katedra za medicinsku mikrobiologiju i parazitologiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Babić-Erceg, AndreaUNSPECIFIED
Vilibić-Čavlek, TatjanaUNSPECIFIED
Erceg, MarijanUNSPECIFIED
Mlinarić-Missoni, EmilijaUNSPECIFIED
Begovac, JosipUNSPECIFIED
Date: June 2014
Date Deposited: 01 Oct 2014 12:09
Last Modified: 01 Oct 2014 12:09
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2159

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