Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease

Babić, Mirjana and Švob Štrac, Dubravka and Mück-Šeler, Dorotea and Pivac, Nela and Stanić, Gabrijela and Hof, Patrick R. and Šimić, Goran (2014) Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease. Croatian Medical Journal, 55 (4). pp. 347-365. ISSN 0353-9504

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Alzheimer disease (AD) is a complex neurodegenerative disorder, whose prevalence will dramatically rise by 2050. Despite numerous clinical trials investigating this disease, there is still no effective treatment. Many trials showed negative or inconclusive results, possibly because they recruited only patients with severe disease, who had not undergone disease-modifying therapies in preclinical stages of AD before severe degeneration occurred. Detection of AD in asymptomatic at risk individuals (and a few presymptomatic individuals who carry an autosomal dominant monogenic AD mutation) remains impractical in many of clinical situations and is possible only with reliable biomarkers. In addition to early diagnosis of AD, biomarkers should serve for monitoring disease progression and response to therapy. To date, the most promising biomarkers are cerebrospinal fluid (CSF) and neuroimaging biomarkers. Core CSF biomarkers (amyloid β1-42, total tau, and phosphorylated tau) showed a high diagnostic accuracy but were still unreliable for preclinical detection of AD. Hence, there is an urgent need for detection and validation of novel CSF biomarkers that would enable early diagnosis of AD in asymptomatic individuals. This article reviews recent research advances on biomarkers for AD, focusing mainly on the CSF biomarkers. In addition to core CSF biomarkers, the potential usefulness of novel CSF biomarkers is discussed.

Item Type: Article
MeSH: Alzheimer Disease / blood ; Alzheimer Disease / cerebrospinal fluid ; Alzheimer Disease / diagnosis ; Alzheimer Disease / genetics ; Amyloid beta-Peptides / cerebrospinal fluid ; Biomarkers / blood ; Biomarkers / cerebrospinal fluid ; Early Diagnosis ; Humans ; Magnetic Resonance Imaging ; Phosphorylation ; tau Proteins / cerebrospinal fluid ; tau Proteins / metabolism
Departments: Hrvatski institut za istraživanje mozga
Katedra za anatomiju i kliničku anatomiju
Depositing User: Marijan Šember
Status: Published
Švob Štrac, DubravkaUNSPECIFIED
Mück-Šeler, DoroteaUNSPECIFIED
Stanić, GabrijelaUNSPECIFIED
Date: 28 August 2014
Date Deposited: 29 Sep 2014 08:47
Last Modified: 16 Jul 2020 08:27
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2152

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