Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men

Golubić, Karlo and Šmalcelj, Anton and Sertić, Jadranka and Juričić, Ljiljana (2014) Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men. Croatian Medical Journal, 55 (1). pp. 38-44. ISSN 0353-9504

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Abstract

AIM: To determine the association between the number of thymine-adenine (TA)n dinucleotide repeats in the promoter region of the gene coding for the estrogen receptor alpha (ESR1) and the prevalence of lone atrial fibrillation (AF) in men. ----- METHODS: We conducted a case-control study involving 89 men with lone AF and 166 healthy male controls. The ESR1 genotype was established by polymerase chain reaction and capillary electrophoresis. To assess the association of ESR1 genotype with AF, logistic regression models were built with AF as outcome. ----- RESULTS: Men with lone AF had significantly greater number of (TA)n repeats of single alleles than controls (mean ± standard deviation, 19.2 ± 4.2 vs 18 ± 4.3, P = 0.010). After adjustment for other factors, a unit-increase in (TA)n repeat number was associated with a significantly greater likelihood of AF (odds ratio 1.069; 95% confidence interval 1.024-1.116, P=0.002). ----- CONCLUSIONS: Our results indicate that a greater number of (TA)n repeats in the promoter region of ESR1 is associated with a significantly increased likelihood of lone atrial fibrillation in men.

Item Type: Article
MeSH: Alleles ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/genetics ; Blood Pressure ; Case-Control Studies ; Dinucleotide Repeats/genetics ; Electrocardiography ; Estrogen Receptor alpha/genetics ; Genotype ; Humans ; Logistic Models ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Promoter Regions, Genetic/genetics
Departments: Katedra za internu medicinu
Katedra za medicinsku kemiju, biokemiju i kliničku kemiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Golubić, KarloUNSPECIFIED
Šmalcelj, AntonUNSPECIFIED
Sertić, JadrankaUNSPECIFIED
Juričić, LjiljanaUNSPECIFIED
Date: February 2014
Date Deposited: 24 Sep 2014 12:35
Last Modified: 24 Sep 2014 12:35
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2144

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